R
Rakesh K. Jain
Researcher at Harvard University
Publications - 1528
Citations - 198912
Rakesh K. Jain is an academic researcher from Harvard University. The author has contributed to research in topics: Angiogenesis & Cancer. The author has an hindex of 200, co-authored 1467 publications receiving 177727 citations. Previous affiliations of Rakesh K. Jain include Government Medical College, Thiruvananthapuram & University of Oslo.
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1995 Whitaker Lecture: delivery of molecules, particles, and cells to solid tumors.
TL;DR: A paradigm of analysis and synthesis has allowed us to obtain a better understanding of physiological barriers in solid tumors, and to develop novel strategies to exploit and/or to overcome these barriers for improved cancer detection and treatment.
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Transgenic Mice for cGMP Imaging
Martin Thunemann,Lai Wen,Matthias Hillenbrand,Angelos Vachaviolos,Susanne Feil,Thomas Ott,Xiaoxing Han,Dai Fukumura,Rakesh K. Jain,Michael Russwurm,Cor de Wit,Robert Feil +11 more
TL;DR: These cGi500 transgenic mice permit the visualization of cardiovascular cG MP signals in live cells, tissues, and mice under normal and pathological conditions or during pharmacotherapy with cGMP-elevating drugs.
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Efficacy and Biomarker Study of Bevacizumab for Hearing Loss Resulting From Neurofibromatosis Type 2–Associated Vestibular Schwannomas
Jaishri O. Blakeley,Xiaobu Ye,Dan G. Duda,Chris Halpin,Amanda L. Bergner,Alona Muzikansky,Vanessa L. Merker,Elizabeth R. Gerstner,Laura M. Fayad,Shivani Ahlawat,Michael A. Jacobs,Rakesh K. Jain,Christopher K. Zalewski,Eva Dombi,Brigitte C. Widemann,Scott R. Plotkin +15 more
TL;DR: Bvacizumab treatment resulted in durable hearing response in 36% of patients with NF2 and confirmed progressive VS-associated hearing loss and imaging and plasma biomarkers showed promising associations with response that should be validated in larger studies.
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Solid stress facilitates spheroid formation: potential involvement of hyaluronan
Chieko Koike,Trevor D. McKee,Trevor D. McKee,Alain Pluen,Saroja Ramanujan,K Burton,Lance L. Munn,Yves Boucher,Rakesh K. Jain +8 more
TL;DR: It is shown that solid stress facilitates the formation of spheroids in the highly metastatic Dunning R3327 rat prostate carcinoma AT3.1 cells, and it is suggested that cell–cell adhesion may be adequate for spheroid formation, whereas solid stress may be required to form sp Heroids when cell–matrix adhesion is predominant.
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A microcosm study on bioremediation of p-nitrophenol-contaminated soil using Arthrobacter protophormiae RKJ100.
TL;DR: The results indicate that strain RKJ100 has potential for use in in situ bioremediation of PNP-contaminated sites and is a model study that could be used for decontamination of sites contaminated also with other compounds.