R
Rakesh K. Jain
Researcher at Harvard University
Publications - 1528
Citations - 198912
Rakesh K. Jain is an academic researcher from Harvard University. The author has contributed to research in topics: Angiogenesis & Cancer. The author has an hindex of 200, co-authored 1467 publications receiving 177727 citations. Previous affiliations of Rakesh K. Jain include Government Medical College, Thiruvananthapuram & University of Oslo.
Papers
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Journal ArticleDOI
Non-invasive monitoring of chronic liver disease via near-infrared and shortwave-infrared imaging of endogenous lipofuscin.
Mari Saif,Wilhelmus J. Kwanten,Wilhelmus J. Kwanten,Jessica A. Carr,Ivy X. Chen,Jessica M. Posada,Jessica M. Posada,Amitabh Srivastava,Juanye Zhang,Yi Zheng,Matthias Pinter,Matthias Pinter,Sampurna Chatterjee,Samir Softic,Samir Softic,Samir Softic,C. Ronald Kahn,Klaus van Leyen,Oliver T. Bruns,Rakesh K. Jain,Moungi G. Bawendi +20 more
TL;DR: It is shown that the endogenous pigment lipofuscin displays strong near-infrared and shortwave-inf infrared fluorescence when excited at 808 nm, enabling label-free imaging of liver injury in mice and the discrimination of pathological processes from normal liver processes with high specificity and sensitivity.
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Vascular permeability and interstitial diffusion of macromolecules in the hamster cheek pouch: Effects of vasoactive drugs
TL;DR: A simple one-dimensional mathematical model which relates the number of "leaky" sites in postcapillary venules to the extravasation of macromolecules in terms of an effective microvascular permeability, P, and an effective interstitial diffusion coefficient, D, is developed and is used to analyze data for the transport of 70,000 molecular weight dextran in a hamster cheek pouch.
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Sunitinib monotherapy in patients with advanced hepatocellular carcinoma (HCC): Insights from a multidisciplinary phase II study
Andrew X. Zhu,Dushyant V. Sahani,E. di Tomaso,Dan G. Duda,Onofrio A. Catalano,Marek Ancukiewicz,Lawrence S. Blaszkowsky,Thomas A. Abrams,David P. Ryan,Rakesh K. Jain +9 more
TL;DR: Sunitinib (SU) as discussed by the authors is an oral, multitargeted tyrosine molecule that is used to treat HCC and angiogenic pathways such as VEGF and IL-6.
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Systemic Distribution and Tumor Localization of Adoptively Transferred Lymphocytes in Mice: Comparison with Physiologically Based Pharmacokinetic Model
Robert J. Melder,Lance L. Munn,Brian R. Stoll,Edgardo Marecos,Laurence T. Baxter,Ralph Weissleder,Rakesh K. Jain +6 more
TL;DR: A physiologically based compartmental model of lymphocyte distribution predicted the compartmental sequestration and identified model parameters critical for experimental planning and therapeutic optimization.
Journal Article
Early events of metastasis in the microcirculation involve changes in gene expression of cancer cells. Tracking mRNA levels of metastasizing cancer cells in the chick embryo chorioallantoic membrane.
TL;DR: Using the CAM system, an alteration of gene expression in cancer cells in the early phases of metastasis is observed, most likely as a consequence of host-cancer cell interactions, which may influence the metastatic behavior of cancer cells.