Kyoto University

About: Kyoto University is a education organization based out in Kyoto, Japan. It is known for research contribution in the topics: Catalysis & Population. The organization has 85837 authors who have published 217215 publications receiving 6526826 citations. The organization is also known as: Kyōto University & Kyōto daigaku.

Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain

Abstract: Neurogenesis occurs continuously in the forebrain of adult mammals, but the functional importance of adult neurogenesis is still unclear. Here, using a genetic labeling method in adult mice, we found that continuous neurogenesis results in the replacement of the majority of granule neurons in the olfactory bulb and a substantial addition of granule neurons to the hippocampal dentate gyrus. Genetic ablation of newly formed neurons in adult mice led to a gradual decrease in the number of granule cells in the olfactory bulb, inhibition of increases in the granule cell number in the dentate gyrus and impairment of behaviors in contextual and spatial memory, which are known to depend on hippocampus. These results suggest that continuous neurogenesis is required for the maintenance and reorganization of the whole interneuron system in the olfactory bulb, the modulation and refinement of the existing neuronal circuits in the dentate gyrus and the normal behaviors involved in hippocampal-dependent memory.

Induced pluripotent stem cell technology: a decade of progress

Abstract: Since the advent of induced pluripotent stem cell (iPSC) technology a decade ago, human iPSCs have been widely used for disease modelling, drug discovery and cell therapy development. This article discusses progress in applications of iPSC technology that are particularly relevant to drug discovery and regenerative medicine, including the powerful combination of human iPSC technology with recent developments in gene editing.

Holographic Entanglement Entropy: An Overview

Abstract: In this paper, we review recent progress on the holographic understanding of the entanglement entropy in the anti-de Sitter space/conformal field theory (AdS/CFT) correspondence. In general, the AdS/CFT relates physical observables in strongly coupled quantum many-body systems to certain classical quantities in gravity plus matter theories. In the case of our holographic entanglement entropy, its gravity dual turns out to be purely geometric, i.e. the area of minimal area surfaces in AdS spaces. One interesting application is to study various phase transitions by regarding the entanglement entropy as order parameters. Indeed we will see that our holographic calculations nicely reproduce the confinement/deconfinement transition. Our results can also be applied to understanding the microscopic origins of black hole entropy.