University of California

About: University of California is a education organization based out in Oakland, California, United States. It is known for research contribution in the topics: Population & Layer (electronics). The organization has 55175 authors who have published 52933 publications receiving 1491169 citations. The organization is also known as: UC & University of California System.

The amyloid precursor protein: beyond amyloid.

Abstract: The amyloid precursor protein (APP) takes a central position in Alzheimer's disease (AD) pathogenesis: APP processing generates the β-amyloid (Aβ) peptides, which are deposited as the amyloid plaques in brains of AD individuals; Point mutations and duplications of APP are causal for a subset of early onset of familial Alzheimer's disease (FAD). Not surprisingly, the production and pathogenic effect of Aβ has been the central focus in AD field. Nevertheless, the biological properties of APP have also been the subject of intense investigation since its identification nearly 20 years ago as it demonstrates a number of interesting putative physiological roles. Several attractive models of APP function have been put forward recently based on in vitro biochemical studies. Genetic analyses of gain- and loss-of-function mutants in Drosophila and mouse have also revealed important insights into its biological activities in vivo. This article will review the current understanding of APP physiological functions.

Human cytochromes P450 in health and disease

Abstract: There are 18 mammalian cytochrome P450 (CYP) families, which encode 57 genes in the human genome. CYP2, CYP3 and CYP4 families contain far more genes than the other 15 families; these three families are also the ones that are dramatically larger in rodent genomes. Most (if not all) genes in the CYP1, CYP2, CYP3 and CYP4 families encode enzymes involved in eicosanoid metabolism and are inducible by various environmental stimuli (i.e. diet, chemical inducers, drugs, pheromones, etc.), whereas the other 14 gene families often have only a single member, and are rarely if ever inducible or redundant. Although the CYP2 and CYP3 families can be regarded as largely redundant and promiscuous, mutations or other defects in one or more genes of the remaining 16 gene families are primarily the ones responsible for P450-specific diseases-confirming these genes are not superfluous or promiscuous but rather are more directly involved in critical life functions. P450-mediated diseases comprise those caused by: aberrant steroidogenesis; defects in fatty acid, cholesterol and bile acid pathways; vitamin D dysregulation and retinoid (as well as putative eicosanoid) dysregulation during fertilization, implantation, embryogenesis, foetogenesis and neonatal development.

Vortex Counting and Lagrangian 3-manifolds

Abstract: To every 3-manifold M one can associate a two-dimensional N=(2,2) supersymmetric field theory by compactifying five-dimensional N=2 super-Yang–Mills theory on M. This system naturally appears in the study of half-BPS surface operators in four-dimensional N=2 gauge theories on one hand, and in the geometric approach to knot homologies, on the other. We study the relation between vortex counting in such two-dimensional N=(2,2) supersymmetric field theories and the refined BPS invariants of the dual geometries. In certain cases, this counting can also be mapped to the computation of degenerate conformal blocks in two-dimensional CFT’s. Degenerate limits of vertex operators in CFT receive a simple interpretation via geometric transitions in BPS counting.

Laplacian Pyramid Reconstruction and Refinement for Semantic Segmentation

Abstract: CNN architectures have terrific recognition performance but rely on spatial pooling which makes it difficult to adapt them to tasks that require dense, pixel-accurate labeling. This paper makes two contributions: (1) We demonstrate that while the apparent spatial resolution of convolutional feature maps is low, the high-dimensional feature representation contains significant sub-pixel localization information. (2) We describe a multi-resolution reconstruction architecture based on a Laplacian pyramid that uses skip connections from higher resolution feature maps and multiplicative gating to successively refine segment boundaries reconstructed from lower-resolution maps. This approach yields state-of-the-art semantic segmentation results on the PASCAL VOC and Cityscapes segmentation benchmarks without resorting to more complex random-field inference or instance detection driven architectures.

Robust memristors based on layered two-dimensional materials

Abstract: Van der Waals heterostructure based on layered two-dimensional (2D) materials offers unprecedented opportunities to create materials with atomic precision by design. By combining superior properties of each component, such heterostructure also provides possible solutions to address various challenges of the electronic devices, especially those with vertical multilayered structures. Here, we report the realization of robust memristors for the first time based on van der Waals heterostructure of fully layered 2D materials (graphene/MoS2-xOx/graphene) and demonstrate a good thermal stability lacking in traditional memristors. Such devices have shown excellent switching performance with endurance up to 107 and a record-high operating temperature up to 340oC. By combining in situ high-resolution TEM and STEM studies, we have shown that the MoS2-xOx switching layer, together with the graphene electrodes and their atomically sharp interfaces, are responsible for the observed thermal stability at elevated temperatures. A well-defined conduction channel and a switching mechanism based on the migration of oxygen ions were also revealed. In addition, the fully layered 2D materials offer a good mechanical flexibility for flexible electronic applications, manifested by our experimental demonstration of a good endurance against over 1000 bending cycles. Our results showcase a general and encouraging pathway toward engineering desired device properties by using 2D van der Waals heterostructures.