Institution
University of California
Education•Oakland, California, United States•
About: University of California is a education organization based out in Oakland, California, United States. It is known for research contribution in the topics: Population & Layer (electronics). The organization has 55175 authors who have published 52933 publications receiving 1491169 citations. The organization is also known as: UC & University of California System.
Topics: Population, Layer (electronics), Cancer, Context (language use), Gene
Papers published on a yearly basis
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TL;DR: In this article, the authors prove d-linear analogues of the classical restriction and Kakeya conjectures in Rd. 1, and give some applications to the corresponding variable-coefficient problems and the so-called joints problem.
Abstract: We prove d-linear analogues of the classical restriction and Kakeya conjectures in Rd. Our approach involves obtaining monotonicity formulae pertaining to a certain evolution of families of gaussians, closely related to heat flow. We conclude by giving some applications to the corresponding variable-coefficient problems and the so-called “joints” problem, as well as presenting some n-linear analogues for n < d.
350 citations
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TL;DR: Implicit sequence learning by the nondominant left hand was examined with the serial reaction time (SRT) task during functional brain imaging, and mirror transformation of the sequence by the right hand was associated with a marked increase in regional activity in the left motor cortex, consistent with a role for sequential transformation at this level of the motor output pathway.
Abstract: Whereas the human right hemisphere is active during execution of contralateral hand movements, the left hemisphere is engaged for both contra- and ipsilateral movements, at least for right-handed subjects. Whether this asymmetry is also found during motor learning remains unknown. Implicit sequence learning by the nondominant left hand was examined with the serial reaction time (SRT) task during functional brain imaging. As learning progressed, increases in brain activity were observed in left lateral premotor cortex (PMC) and bilaterally in supplementary motor areas (SMA), with the increase significantly greater in the left hemisphere. The left SMA site was similar to one previously identified with right-hand learning, suggesting that this region is critical for representing a sequence independent of effector. Learning with the left hand also recruited a widespread set of temporal and frontal regions, suggesting that motor skill learning with the nondominant hand develops within both cognitive and motor-related functional networks. After skill acquisition, subjects performed the SRT task with their right hands, and sequence transfer was tested with the original and a mirror-ordered sequence. With the original sequence, the stimulus sequence and series of response locations remained unchanged, but the finger movements were different. With the mirror-ordered sequence, the response sequence involved finger movements homologous to those used during training. Performance of the original and mirror sequence by the right hand was significantly better than with random stimuli. Mirror transformation of the sequence by the right hand was associated with a marked increase in regional activity in the left motor cortex, consistent with a role for sequential transformation at this level of the motor output pathway.
350 citations
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TL;DR: In this paper, a characteristic intensity of a feature in image data generated by scanning a microarray probe is determined (304), and a set of pixels of the image data that nominally represent the feature is identified.
Abstract: A characteristic intensity of a feature in image data generated by scanning a microarray probe is determined (304). A set of pixels of the image data that nominally represent the feature is identified. The pixels each have a value (such as an intensity value) associated therewith. For each of a plurality of subsets of the set of pixels, a variation statistic value is determined that corresponds to a variation in the values associated with the pixels of that subset (Fig.3).
349 citations
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04 Dec 1996TL;DR: In this paper, binding agents that block CTLA-4 signaling are used to increase the T cell activation in response to antigen, which is useful for the treatment of tumors, chronic viral infections, and as an adjuvant during immunization.
Abstract: T cell activation in response to antigen is increased by the administration of binding agents that block CTLA-4 signaling. When CTLA-4 signaling is thus blocked, the T cell response to antigen is released from inhibition. Such an enhanced response is useful for the treatment of tumors, chronic viral infections, and as an adjuvant during immunization.
349 citations
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Northern Illinois University1, BirdLife International2, University of California, Santa Cruz3, Oregon State University4, University College Cork5, Massey University6, University of Queensland7, Landcare Research8, Royal Society for the Protection of Birds9, United States Fish and Wildlife Service10, International Union for Conservation of Nature and Natural Resources11, National Audubon Society12, Wellington Management Company13, Laney College14, Island Conservation Society15, University of Auckland16, University of Otago17, Auckland University of Technology18, University of California19
TL;DR: The global benefits of an increasingly used conservation action to stem biodiversity loss: eradication of invasive mammals on islands are estimated to be 107 highly threatened birds, mammals, and reptiles on the IUCN Red List—6% of all these highly threatened species—likely have benefitted from invasive mammal eradications on islands.
Abstract: More than US$21 billion is spent annually on biodiversity conservation. Despite their importance for preventing or slowing extinctions and preserving biodiversity, conservation interventions are rarely assessed systematically for their global impact. Islands house a disproportionately higher amount of biodiversity compared with mainlands, much of which is highly threatened with extinction. Indeed, island species make up nearly two-thirds of recent extinctions. Islands therefore are critical targets of conservation. We used an extensive literature and database review paired with expert interviews to estimate the global benefits of an increasingly used conservation action to stem biodiversity loss: eradication of invasive mammals on islands. We found 236 native terrestrial insular faunal species (596 populations) that benefitted through positive demographic and/or distributional responses from 251 eradications of invasive mammals on 181 islands. Seven native species (eight populations) were negatively impacted by invasive mammal eradication. Four threatened species had their International Union for the Conservation of Nature (IUCN) Red List extinction-risk categories reduced as a direct result of invasive mammal eradication, and no species moved to a higher extinction-risk category. We predict that 107 highly threatened birds, mammals, and reptiles on the IUCN Red List-6% of all these highly threatened species-likely have benefitted from invasive mammal eradications on islands. Because monitoring of eradication outcomes is sporadic and limited, the impacts of global eradications are likely greater than we report here. Our results highlight the importance of invasive mammal eradication on islands for protecting the world's most imperiled fauna.
349 citations
Authors
Showing all 55232 results
Name | H-index | Papers | Citations |
---|---|---|---|
Meir J. Stampfer | 277 | 1414 | 283776 |
George M. Whitesides | 240 | 1739 | 269833 |
Michael Karin | 236 | 704 | 226485 |
Fred H. Gage | 216 | 967 | 185732 |
Rob Knight | 201 | 1061 | 253207 |
Martin White | 196 | 2038 | 232387 |
Simon D. M. White | 189 | 795 | 231645 |
Scott M. Grundy | 187 | 841 | 231821 |
Peidong Yang | 183 | 562 | 144351 |
Patrick O. Brown | 183 | 755 | 200985 |
Michael G. Rosenfeld | 178 | 504 | 107707 |
George M. Church | 172 | 900 | 120514 |
David Haussler | 172 | 488 | 224960 |
Yang Yang | 171 | 2644 | 153049 |
Alan J. Heeger | 171 | 913 | 147492 |