Anthropometry, carbohydrate and lipid metabolism in the East Flanders Prospective Twin Survey: heritabilities
N Y Souren,Aimee D C Paulussen,Aimee D C Paulussen,Ruth J. F. Loos,Ruth J. F. Loos,Marij Gielen,Gaston Beunen,Robert Fagard,Catherine Derom,Robert Vlietinck,Maurice P. Zeegers,Maurice P. Zeegers +11 more
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Genetic factors explain the greater part of the variation in traits related to obesity, glucose intolerance/insulin resistance and dyslipidaemia.Abstract:
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We determined the genetic contribution of 18 anthropometric and metabolic risk factors of type 2 diabetes using a young healthy twin population.read more
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Journal ArticleDOI
Methodology for Genetic Studies of Twins and Families
TL;DR: The saimie paper suggests how susceptible individuals could reduce their total intake of aluminium and suggests that although definite proof is still lacking, there is more than enough evidence to fuel further epidemiological investigation.
Journal ArticleDOI
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
Iris M. Heid,Anne U. Jackson,Joshua C. Randall,Tthomas W. Winkler,Llu Qi,Valgerdur Ssteinthorsdottir,Ggudmar Tthorleifsson,Ccarola Zillikens,Eelizabeth K. Sspeliotes,Eelizabeth K. Sspeliotes,Reedik Mägi,Tsegaselassie Workalemahu,Charles S. White,Nabila Bouatia-Naji,Nabila Bouatia-Naji,Tamara B. Harris,Ssonja I. Berndt,Eerik Ingelsson,Cristen J. Willer,Michael N. Weedon,Jian'an Luan,Ssailaja Vedantam,Ssailaja Vedantam,Tõnu Eesko,Tuomas O. Kilpeläinen,Zoltán Kutalik,Zoltán Kutalik,Sshengxu Li,Keri L. Monda,Anna L. Dixon,Christopher Holmes,Lee M. Kaplan,Liming Liang,J L Min,Miriam F. Moffatt,Cliona Molony,Ggeorge Nicholson,Eeric E. Sschadt,Eeric E. Sschadt,Krina T. Zondervan,Mary F. Feitosa,Teresa Ferreira,Hana Lango Allen,Robert J. Weyant,Eeleanor Wheeler,Andrew R. Wood,Karol Eestrada,Micheal E. Goddard,Micheal E. Goddard,Guillaume Lettre,Massimo Mangino,Dale R. Nyholt,Sshaun Purcell,Sshaun Purcell,Albert Vernon Ssmith,Peter M. Visscher,Jian Yang,Ssteven A. McCcarroll,Ssteven A. McCcarroll,James Nemesh,Benjamin F. Voight,Benjamin F. Voight,Devin Absher,Najaf Amin,Thor Aspelund,Lachlan J. M. Coin,Nicole L. Glazer,Caroline Hayward,Nancy Heard-Ccosta,Jouke-Jan Hottenga,Åsa Johansson,Åsa Johansson,Toby Johnson,Toby Johnson,Toby Johnson,Marika Kaakinen,Karen Kapur,Karen Kapur,Sshamika Ketkar,Joshua W. Knowles,Peter Kraft,Aldi T. Kraja,Claudia Lamina,Micheal F. Leitzmann,Barbara McKknight,Andrew P. Morris,Ken Oong,John R. B. Perry,Marjolein J. Peters,Oozren Polasek,Inga Prokopenko,Nigel W. Rayner,Ssamuli Ripatti,Ssamuli Ripatti,Fernando Rivadeneira,Neil R. Robertson,Serena Sanna,Ulla Sovio,Ida Surakka,Ida Surakka,Alexander Teumer,Sophie H. Van Wingerden,Veronique Vitart,Jing Hua Zhao,Christine Cavalcanti-Proença,Christine Cavalcanti-Proença,Peter S. Chines,Eeva Fisher,Jennifer R. Kulzer,Cécile Lecoeur,Cécile Lecoeur,Narisu Narisu,Camilla H. Sandholt,Laura J. Scott,Kaisa Silander,Kaisa Silander,Klaus Stark,Mari Lliis Tammesoo,Tanya M. Teslovich,Nicholas J. Timpson,Richard M. Watanabe,Ryan P. Welch,Daniel I. Chasman,Mark E. Cooper,John Oolov Jansson,Johannes Kettunen,Johannes Kettunen,Robert Wlawrence,Niina Pellikka,Niina Pellikka,Markus Perola,Markus Perola,Liesbeth Vandenput,Helene Alavere,Peter Almgren,Larry D. Atwood,Amanda J. Bennett,Reiner Biffar,Lori L. Bonnycastle,Stefan R. Bornstein,Thomas A. Buchanan,Harry Campbell,Ian N. M. Day,Mariano Dei,Marcus Dörr,Paul Eelliott,Paul Eelliott,Michael R. Eerdos,Johan G. Eeriksson,Nelson B. Freimer,Mao Fu,Stefan Gaget,Stefan Gaget,Eeco J.C. Geus,Anette P. Gjesing,Harald Grallert,Jürgen Gräßler,Christopher J. Groves,Candace Guiducci,Anna Lliisa Hartikainen,Neelam Hassanali,Aki S. Havulinna,Karl-Heinz Herzig,Karl-Heinz Herzig,Andrew A. Hicks,Jennie Hui,Jennie Hui,Wilmar Igl,Pekka Jousilahti,Antti Jula,Eeero Kajantie,Leena Kinnunen,Ivana Kolcic,Seppo Koskinen,Peter Kovacs,Heyo K. Kroemer,Vjekoslav Krzelj,Johanna Kuusisto,Kirsti Kvaløy,Jaana Laitinen,Oolivier Lantieri,Mark Lathrop,Marja Llokki Lokki,Robert Luben,Barbara Ludwig,Wendy L. McArdle,Anne McCcarthy,Mario A. Morken,Mari Nelis,Mari Nelis,Matt Neville,Guillaume Paré,Alex N. Parker,John F. Peden,Irene Pichler,Kirsi H. Pietiläinen,Carl G. P. Platou,Anneli Pouta,Anneli Pouta,Martin Ridderstråle,Nilesh J. Samani,Nilesh J. Samani,Jouko Saramies,Juha Sinisalo,Jan Smit,Rona J. Strawbridge,Heather M. Stringham,Amy J. Swift,Maris Teder-Llaving,Maris Teder-Llaving,Brian Thomson,Gianluca Usala,Joyce B.J. Van Mmeurs,Gert-Jan B. van Ommen,Vincent Vatin,Vincent Vatin,Claudia B. Volpato,Henri Wallaschofski,Bragi Walters,Eelisabeth Widen,Sarah H. Wild,Gonneke Willemsen,Deniel R. Witte,Lina Zgaga,Paavo Zitting,John Beilby,John Beilby,Alan L. James,Alan L. James,Mika Kähönen,Terho Lehtimäki,Markku S. Nieminen,Claes Ohlsson,Lyle J. Palmer,Lyle J. Palmer,Olli T. Raitakari,Paul M. Ridker,Micheal Stumvoll,Anke Tönjes,Jorma Viikari,Beverley Balkau,Yoav Ben-Shlomo,Richard N. Bergman,Heiner Boeing,George Ddavey Smith,Shah Eebrahim,Philippe Froguel,Philippe Froguel,Philippe Froguel,Torben Hansen,Torben Hansen,Christian Hengstenberg,Kristian Hveem,Bo Isomaa,Torben Jørgensen,Fredrik Karpe,Kay Ttee Khaw,Markku Laakso,Debbie A Lawlor,Michel Marre,Michel Marre,Thomas Meitinger,Andres Metspalu,Andres Metspalu,Kristian Midthjell,Oluf Pedersen,Oluf Pedersen,Oluf Pedersen,Veikko Salomaa,Peter Schwarz,Tiinamaija Tuomi,Jaakko Tuomilehto,Jaakko Tuomilehto,Timo T. Valle,Nicholas J. Wareham,Alice M. Arnold,Jacques S. Beckmann,Sven Bergmann,Sven Bergmann,Eeric Boerwinkle,Dorret I. Boomsma,Mark J. Caulfield,Francis S. Collins,Gudny Eeiriksdottir,Vilmundur Gudnason,Ulf Gyllensten,Anders Hamsten,Andrew T. Hattersley,Albert Hofman,Frank B. Hu,Thomas Illig,Carlos Iribarren,Carlos Iribarren,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,W. H. Linda Kao,Jaakko Kaprio,Jaakko Kaprio,Lenore J. Launer,Patricia B. Munroe,Ben A. Oostra,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Brenda W.J.H. Penninx,Peter P. Pramstaller,Bruce M. Psaty,Bruce M. Psaty,Thomas Quertermous,Aila Rissanen,Igor Rudan,Igor Rudan,Alan R. Shuldiner,Alan R. Shuldiner,Nicole Soranzo,Nicole Soranzo,Tim D. Spector,Ann Cchristine Syvanen,Manuela Uda,André G. Uitterlinden,Henry Völzke,Peter Vollenweider,James F. Wilson,Jacqueline C. M. Witteman,Alan F. Wright,Gonçalo R. Abecasis,M Boehnke,Ingrid B. Borecki,Panos Deloukas,Timothy M. Frayling,Leif Groop,Talin Haritunians,David J. Hunter,Robert C. Kaplan,Kari E. North,Jeffrey R. O'Cconnell,Leena Peltonen,David Schlessinger,David P. Strachan,Joel N. Hirschhorn,Joel N. Hirschhorn,Themistocles L. Assimes,H. Eerich Wichmann,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Cornelia Van Dduijn,Kari Stefansson,Kari Stefansson,Adrienne Cupples,Ruth J. F. Loos,Inês Barroso,Inês Barroso,Mark I. McCcarthy,Caroline S. Fox,Karen L. Mohlke,Cecilia M. Lindgren +355 more
TL;DR: A meta-analysis of genome-wide association studies for WHR adjusted for body mass index provides evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.
Journal ArticleDOI
Genome-wide association analysis of metabolic traits in a birth cohort from a founder population
Chiara Sabatti,Anna-Liisa Hartikainen,Anneli Pouta,Samuli Ripatti,Jae Brodsky,Christopher G. Jones,Noah Zaitlen,Teppo Varilo,Marika Kaakinen,Ulla Sovio,Aimo Ruokonen,Jaana Laitinen,Eveliina Jakkula,Lachlan J. M. Coin,Clive J. Hoggart,Andrew Collins,Hannu Turunen,Stacey Gabriel,Paul Elliot,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Mark J. Daly,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Nelson B. Freimer,Nelson B. Freimer,Leena Peltonen,Leena Peltonen,Leena Peltonen +29 more
TL;DR: The association observed between low-density lipoprotein and an infrequent variant in AR suggests the potential of such a cohort for identifying associations with both common, low-impact and rarer, high-impact quantitative trait loci.
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
Iris M. Heid,Anne U. Jackson,Joshua C. Randall,Thomas W. Winkler,Lu Qi,Valgerdur Steinthorsdottir,Gudmar Thorleifsson,M. Carola Zillikens,Elizabeth K. Speliotes,Reedik Maegi,Tsegaselassie Workalemahu,Charles C. White,Nabila Bouatia-Naji,Tamara B. Harris,Sonja I. Berndt,Erik Ingelsson,Cristen J. Willer,Michael N. Weedon,Jian'an Luan,Sailaja Vedantam,Tõnu Esko,Tuomas O. Kilpelaeinen,Zoltán Kutalik,Shengxu Li,Keri L. Monda,Anna L. Dixon,Christopher Holmes,Lee M. Kaplan,Liming Liang,Josine L. Min,Miriam F. Moffatt,Cliona Molony,George Nicholson,Eric E. Schadt,Krina T. Zondervan,Mary F. Feitosa,Teresa Ferreira,Hana Lango Allen,Robert J. Weyant,Eleanor Wheeler,Andrew R. Wood,Karol Estrada,Michael E. Goddard,Guillaume Lettre,Massimo Mangino,Dale R. Nyholt,Shaun Purcell,Albert V. Smith,Peter M. Visscher,Jian Yang,Steven A. McCarroll,James Nemesh,Benjamin F. Voight,Devin Absher,Najaf Amin,Thor Aspelund,Lachlan J. M. Coin,Nicole L. Glazer,Caroline Hayward,Nancy L. Heard-Costa,Jouke-Jan Hottenga,Åsa Johansson,Toby Johnson,Marika Kaakinen,Karen Kapur,Shamika Ketkar,Joshua W. Knowles,Peter Kraft,Aldi T. Kraja,Claudia Lamina,Michael F. Leitzmann,Barbara McKnight,Andrew P. Morris,Ken K. Ong,John R. B. Perry,Marjolein J. Peters,Ozren Polasek,Inga Prokopenko,Nigel W. Rayner,Samuli Ripatti,Fernando Rivadeneira,Neil R. Robertson,Serena Sanna,Ulla Sovio,Ida Surakka,Alexander Teumer,Sophie van Wingerden,Veronique Vitart,Jing Hua Zhao,Christine Cavalcanti-Proença,Peter S. Chines,Eva Fisher,Jennifer R. Kulzer,Cécile Lecoeur,Narisu Narisu,Camilla H. Sandholt,Laura J. Scott,Kaisa Silander,Klaus Stark,Mari-Liis Tammesoo,Tanya M. Teslovich,Nicholas J. Timpson,Richard M. Watanabe,Ryan P. Welch,Daniel I. Chasman,Mark E. Cooper,John-Olov Jansson,Johannes Kettunen,Robert Lawrence,Niina Pellikka,Markus Perola,Liesbeth Vandenput,Helene Alavere,Peter Almgren,Larry D. Atwood,Amanda J. Bennett,Reiner Biffar,Lori L. Bonnycastle,Stefan R. Bornstein,Thomas A. Buchanan,Harry Campbell,Ian N.M. Day,Mariano Dei,Marcus Doerr,Paul Elliott,Michael R. Erdos,Johan G. Eriksson,Nelson B. Freimer,Mao Fu,Stefan Gaget,Eco J. C. de Geus,Anette P. Gjesing,Harald Grallert,Juergen Graessler,Christopher J. Groves,Candace Guiducci,Anna-Liisa Hartikainen,Neelam Hassanali,Aki S. Havulinna,Karl-Heinz Herzig,Andrew A. Hicks,Jennie Hui,Wilmar Igl,Pekka Jousilahti,Antti Jula,Eero Kajantie,Leena Kinnunen,Ivana Kolcic,Seppo Koskinen,Peter Kovacs,Heyo K. Kroemer,Vjekoslav Krzelj,Johanna Kuusisto,Kirsti Kvaløy,Jaana Laitinen,Olivier Lantieri,G. Mark Lathrop,Marja-Liisa Lokki,Robert Luben,Barbara Ludwig,Wendy L. McArdle,Anne Marie McCarthy,Mario A. Morken,Mari Nelis,Matt Neville,Guillaume Paré,Alex N. Parker,John F. Peden,Irene Pichler,Kirsi H. Pietiläinen,Carl G. P. Platou,Anneli Pouta,Martin Ridderstråle,Nilesh J. Samani,Jouko Saramies,Juha Sinisalo,Jan Smit,Rona J. Strawbridge,Heather M. Stringham,Amy J. Swift,Maris Teder-Laving,Brian Thomson,Gianluca Usala,Joyce B. J. van Meurs,Gert-Jan B. van Ommen,Vincent Vatin,Claudia B. Volpato,Henri Wallaschofski,G. Bragi Walters,Elisabeth Widen,Sarah H. Wild,Gonneke Willemsen,Daniel R. Witte,Lina Zgaga,Paavo Zitting,John Beilby,Alan L. James,Mika Kähönen,Terho Lehtimäki,Markku S. Nieminen,Claes Ohlsson,Lyle J. Palmer,Olli T. Raitakari,Paul M. Ridker,Michael Stumvoll,Anke Toenjes,Jorma Viikari,Beverley Balkau,Yoav Ben-Shlomo,Richard N. Bergman,Heiner Boeing,George Davey Smith,Shah Ebrahim,Philippe Froguel,Torben Hansen,Christian Hengstenberg,Kristian Hveem,Bo Isomaa,Torben Jørgensen,Fredrik Karpe,Kay-Tee Khaw,Markku Laakso,Debbie A Lawlor,Michel Marre,Thomas Meitinger,Andres Metspalu,Kristian Midthjell,Oluf Pedersen,Veikko Salomaa,Peter Schwarz,Tiinamaija Tuomi,Jaakko Tuomilehto,Timo T. Valle,Nicholas J. Wareham,Alice M. Arnold,Jacques S. Beckmann,Sven Bergmann,Eric Boerwinkle,Dorret I. Boomsma,Mark J. Caulfield,Francis S. Collins,Gudny Eiriksdottir,Vilmundur Gudnason,Ulf Gyllensten,Anders Hamsten,Andrew T. Hattersley,Albert Hofman,Frank B. Hu,Thomas Illig,Carlos Iribarren,Marjo-Riitta Järvelin,W. H. Linda Kao,Jaakko Kaprio,Lenore J. Launer,Patricia B. Munroe,Ben A. Oostra,Brenda W.J.H. Penninx,Peter P. Pramstaller,Bruce M. Psaty,Thomas Quertermous,Aila Rissanen,Igor Rudan,Alan R. Shuldiner,Nicole Soranzo,Tim D. Spector,Ann-Christine Syvänen,Manuela Uda,André G. Uitterlinden,Henry Voelzke,Peter Vollenweider,James F. Wilson,Jacqueline C. M. Witteman,Alan F. Wright,Gonçalo R. Abecasis,Michael Boehnke,Ingrid B. Borecki,Panos Deloukas,Timothy M. Frayling,Leif Groop,Talin Haritunians,David J. Hunter,Robert C. Kaplan,Kari E. North,Jeffrey R. O'Connell,Leena Peltonen,David Schlessinger,David P. Strachan,Joel N. Hirschhorn,Themistocles L. Assimes,H-Erich Wichmann,Unnur Thorsteinsdottir,Cornelia M. van Duijn,Kari Stefansson,L. Adrienne Cupples,Ruth J. F. Loos,Inês Barroso,Mark I. McCarthy,Caroline S. Fox,Karen L. Mohlke,Cecilia M. Lindgren +299 more
Journal ArticleDOI
Variability in the Heritability of Body Mass Index: A Systematic Review and Meta-Regression
Cathy E. Elks,Marcel den Hoed,Jing Hua Zhao,Stephen J. Sharp,Nicholas J. Wareham,Ruth J. F. Loos,Ken K. Ong,Ken K. Ong +7 more
TL;DR: The genetic contribution to BMI appears to vary with age and may have a greater influence during childhood than adult life, and study design factors explained nearly half the heterogeneity reported in twin studies.
References
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Journal ArticleDOI
Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results
Eric S. Lander,Leonid Kruglyak +1 more
TL;DR: Specific standards designed to maintain rigor while also promoting communication are proposed for the interpretation of linkage results in genetic studies under way for many complex traits.
Journal ArticleDOI
Merlin--rapid analysis of dense genetic maps using sparse gene flow trees.
TL;DR: The multipoint engine for rapid likelihood inference (Merlin) is a computer program that uses sparse inheritance trees for pedigree analysis; it performs rapid haplotyping, genotype error detection and affected pair linkage analyses and can handle more markers than other pedigree analysis packages.
Book
Methodology for Genetic Studies of Twins and Families
Michael C. Neale,Lon R. Cardon +1 more
TL;DR: The LISREL Script for Rater Bias Model and Data for Simplex Model as mentioned in this paper is one of the most well-known models in the literature for gene expression analysis.
Journal ArticleDOI
A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants.
Laura J. Scott,Karen L. Mohlke,Lori L. Bonnycastle,Cristen J. Willer,Yun Li,William L. Duren,Michael R. Erdos,Heather M. Stringham,Peter S. Chines,Anne U. Jackson,Ludmila Prokunina-Olsson,Chia-Jen Ding,Amy J. Swift,Narisu Narisu,Tianle Hu,Randall Pruim,Rui Xiao,Xiao-Yi Li,Karen N. Conneely,Nancy Riebow,Andrew G. Sprau,Maurine Tong,Peggy P. White,Kurt N. Hetrick,Michael W. Barnhart,Craig W. Bark,Janet L. Goldstein,Lee Watkins,Fang Xiang,Jouko Saramies,Thomas A. Buchanan,Richard M. Watanabe,Timo T. Valle,Leena Kinnunen,Gonçalo R. Abecasis,Elizabeth W. Pugh,Kimberly F. Doheny,Richard N. Bergman,Jaakko Tuomilehto,Francis S. Collins,Michael Boehnke +40 more
TL;DR: The number of T2D loci now confidently identified to at least 10 is confirmed, and it is confirmed that variants near TCF7L2, SLC30A8, HHEX, FTO, PPARG, and KCNJ11 are associated with T1D risk.
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Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth
TL;DR: It is concluded that Type 2 diabetes and hypertension have a common origin in sub-optimal development in utero, and that syndrome X should perhaps be re-named “the small-baby syndrome”.
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PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage Analyses
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
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