Cancer-related inflammation.
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TLDR
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.Citations
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Journal ArticleDOI
Inflammation: a driving force speeds cancer metastasis.
Yadi Wu,Binhua P. Zhou +1 more
TL;DR: New insights into the molecular pathways that link inflammation in the tumor microenvironment to metastasis are reviewed, focusing on the function of proinflammatory factors, particularly cytokines during tumor metastasis.
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The Role of Tumor-Infiltrating Immune Cells and Chronic Inflammation at the Tumor Site on Cancer Development, Progression, and Prognosis: Emphasis on Non-small Cell Lung Cancer
Roy M. Bremnes,Khalid Al-Shibli,Tom Donnem,Rafael Sirera,Samer Al-Saad,Sigve Andersen,Helge Stenvold,Carlos Camps,Lill-Tove Busund +8 more
TL;DR: This review reports on the tumor stroma and in particular tumor-suppressing and -promoting roles of the immune system, and presents recent literature on relevant immune cell-related research in NSCLC.
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Cancer Cells Expressing Toll-like Receptors and the Tumor Microenvironment
TL;DR: This review discusses how carcinogenesis, cancer progression, and site-specific metastasis are related to interactions between cancer cells, immune cells, and DAMPs through TLR activation in the tumor microenvironment.
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Chronic periodontitis and the incidence of head and neck squamous cell carcinoma.
Mine Tezal,Maureen Sullivan,Andrew Hyland,James R. Marshall,Daniel L. Stoler,Mary E. Reid,Thom R. Loree,Nestor R. Rigual,Mihai Merzianu,Linda Hauck,Cheryl Lillis,Jean Wactawski-Wende,Frank A. Scannapieco +12 more
TL;DR: Chronic periodontitis is an independent risk factor for HNSCC and smoking modifies this association, and results have implications for practical and safe strategies for prevention, diagnosis, and treatment of H NSCC.
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Targeting the microenvironment in solid tumors.
Carmen Belli,Dario Trapani,Giulia Viale,Paolo D'Amico,Bruno Achutti Duso,Paolo Della Vigna,Franco Orsi,Giuseppe Curigliano +7 more
TL;DR: Multitargeted approaches, providing a simultaneous inhibition of TME components, may offer a more efficient way to treat cancer.
References
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Journal ArticleDOI
Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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Nuclear factor-kappaB in cancer development and progression.
TL;DR: This article showed that NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms.