Cancer-related inflammation.
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TLDR
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.Citations
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Novel evidence for an oncogenic role of microRNA-21 in colitis-associated colorectal cancer.
Chenzhang Shi,Yongzhi Yang,Yang Xia,Yoshinaga Okugawa,Jun Yang,Yong Liang,Hongqi Chen,Peng Zhang,Feng Wang,Hua-Zhong Han,Wen Wu,Renyuan Gao,Christoph Gasche,Huanlong Qin,Yanlei Ma,Ajay Goel +15 more
TL;DR: Novel evidence for miR-21 blockade to be a key strategy in reducing CAC is provided, following azoxymethane and dextran sulfate sodium intervention and in a mouse model of CAC.
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Cancer-associated fibroblasts, a parameter of the tumor microenvironment, overcomes carcinoma-associated parameters in the prognosis of patients with mobile tongue cancer
Ibrahim O. Bello,Marilena Vered,Marilena Vered,Dan Dayan,Alex Dobriyan,Ran Yahalom,Kalle Alanen,Pentti Nieminen,Saara Kantola,Saara Kantola,Esa Läärä,Tuula Salo,Tuula Salo +12 more
TL;DR: Routine assessment of CAF density for disease course prognosis and inclusion as an integral part of treatment protocols are recommended, given the strong association between increased CAFdensity and higher mortality in MTSCC.
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Experimental mouse tumour models: what can be learnt about human cancer immunology?
TL;DR: Experimental mouse tumour models have provided key mechanistic insights into host antitumour immune responses, and these have guided the development of novel treatment strategies, but investigators need to gain a better understanding of their strengths and limitations.
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Systemic immune-inflammation index predicts the clinical outcome in patients with metastatic renal cell cancer treated with sunitinib
Cristian Lolli,Umberto Basso,Lisa Derosa,Emanuela Scarpi,Teodoro Sava,Matteo Santoni,Simon J. Crabb,Francesco Massari,Michele Aieta,Vincenza Conteduca,Marco Maruzzo,Francesca La Russa,Matthew Wheater,Rossana Berardi,Luca Galli,Ugo De Giorgi +15 more
TL;DR: The SII and its changes during treatment represent a powerful prognostic indicator of clinical outcome in patients with metastatic RCC and was associated with objective response, p < 0.0001.
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The Emerging Role of Neutrophil to Lymphocyte Ratio in Determining Colorectal Cancer Treatment Outcomes: A Systematic Review and Meta-Analysis
George Malietzis,Marco Giacometti,Robin H. Kennedy,Thanos Athanasiou,Omer Aziz,John T. Jenkins +5 more
TL;DR: Elevated preoperative NLR is associated with poorer survival in CRC patients undergoing treatment and may have a role in CRC surveillance programs as a means of delivering more personalized cancer care.
References
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Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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Nuclear factor-kappaB in cancer development and progression.
TL;DR: This article showed that NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms.