Cancer-related inflammation.
TLDR
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.Citations
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Complement C5a Fosters Squamous Carcinogenesis and Limits T Cell Response to Chemotherapy
Terry R. Medler,Dhaarini Murugan,Wesley Horton,Sushil Kumar,Tiziana Cotechini,Alexandra M. Forsyth,Patrick Leyshock,Justin J. Leitenberger,Molly Kulesz-Martin,Adam A. Margolin,Zena Werb,Lisa M. Coussens +11 more
TL;DR: Therapeutic inhibition of C5aR1 via the peptide antagonist PMX-53 improved efficacy of paclitaxel chemotherapy associated with increased presence and cytotoxic properties of CXCR3+ effector memory CD8+ T cells in carcinomas, dependent on both macrophage transcriptional programming and IFNγ.
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IL1 Receptor Antagonist Controls Transcriptional Signature of Inflammation in Patients with Metastatic Breast Cancer.
Te-Chia Wu,Kangling Xu,Jan Martinek,Robyn R. Young,Romain Banchereau,Joshy George,Jacob Turner,Kyung In Kim,Sandra Zurawski,Xuan Wang,Derek Blankenship,Hannah M. Brookes,Florentina Marches,Gerlinde Obermoser,Elizabeth M. Lavecchio,Maren K. Levin,Sookyoung Bae,Cheng-han Chung,Jennifer L. Smith,Alma-Martina Cepika,Kyp L. Oxley,George Snipes,Jacques Banchereau,Virginia Pascual,Joyce O'Shaughnessy,A. Karolina Palucka +25 more
TL;DR: It is shown that production of IL1β in primary breast cancer tumors is linked with advanced disease and originates from tumor-infiltrating CD11c+ myeloid cells, and can be targeted in patients using an IL1 receptor antagonist.
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The elevated NLR, PLR and PLT may predict the prognosis of patients with colorectal cancer: a systematic review and meta-analysis.
TL;DR: It is indicated that elevated neutrophils- to-lymphocytes ratio, platelet-to-ly mphocytes ratio or platelet counts may be a cost-effective and noninvasive serum biomarker for poor prognosis for patients with colorectal cancer.
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The role of CXCL12 in tumor microenvironment.
Wenfang Meng,Shihang Xue,Ye Chen +2 more
TL;DR: Strategies for treating cancer by disrupting this interaction with special emphasis on the CXCR4/CXCL12 axis are summarized.
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Linking tumor-associated macrophages, inflammation, and intestinal tumorigenesis: role of MCP-1.
Jamie L. McClellan,J. Mark Davis,Jennifer L. Steiner,Reilly T. Enos,Seung Ho Jung,James A. Carson,Maria Marjorette O. Peña,Kevin A. Carnevale,Franklin G. Berger,E. Angela Murphy +9 more
TL;DR: It is demonstrated that MCP-1 is an important mediator of tumor growth and immune regulation that may serve as an important biomarker and/or therapeutic target in colon cancer.
References
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Journal ArticleDOI
Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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Nuclear factor-kappaB in cancer development and progression.
TL;DR: This article showed that NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms.