Cancer-related inflammation.
TLDR
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.Citations
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The cancer stem cell niche—there goes the neighborhood?
TL;DR: This review focuses on current evidence demonstrating that homeostatic processes such as inflammation, epithelial to mesenchymal transition, hypoxia and angiogenesis contribute to the maintenance and control of cancer stem cell fate by providing the appropriate signals within the microenvironment.
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Physical activity, diet, adiposity and female breast cancer prognosis: a review of the epidemiologic literature.
TL;DR: A review of the published epidemiologic research on lifestyle and breast cancer outcomes among women with a history of breast cancer is presented in this paper, where the primary outcomes were additional breast cancer events and mortality.
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Targeted delivery of proapoptotic peptides to tumor-associated macrophages improves survival
Maryelise Cieslewicz,Jingjing Tang,Jonathan L. Yu,Hua Cao,Maja Zavaljevski,Koka Motoyama,André Lieber,Elaine W. Raines,Suzie H. Pun +8 more
TL;DR: The discovery of a unique peptide sequence, M2pep, that preferentially binds to murine M2 cells, including TAMs, with low affinity for other leukocytes is reported, and it is suggested that a molecular-targeting approach for TAM depletion is a promising adjunct strategy to add to the arsenal of anticancer therapies.
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Regulation of Mast Cell Responses in Health and Disease
TL;DR: Although mast cells have a sufficient repertoire of bioactive mediators to mount effective innate and adaptive defense mechanisms against invading microorganisms, these same mediators can adversely affect surrounding tissues in the host, resulting in autoimmune disease as well as allergic disorders.
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Modulation of inflammatory genes by natural dietary bioactive compounds.
TL;DR: Current knowledge on natural bioactive compounds that act through the signaling pathways and modulate inflammatory gene expressions are summarized, thus providing evidence for these substances in cancer chemopreventive action.
References
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Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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Nuclear factor-kappaB in cancer development and progression.
TL;DR: This article showed that NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms.