Cancer-related inflammation.
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TLDR
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.Citations
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DEXA measures of body fat percentage and acute phase proteins among breast cancer survivors: a cross-sectional analysis.
Anne Dee,Roberta McKean-Cowdin,Marian L. Neuhouser,Cornelia M. Ulrich,Richard N. Baumgartner,Anne McTiernan,Kathy B. Baumgartner,Catherine M. Alfano,Rachel Ballard-Barbash,Leslie Bernstein +9 more
TL;DR: Assessment of NSAID use and weight control in reducing circulating inflammatory markers among survivors may be worthwhile to investigate in randomized intervention trials as higher inflammatory markers are associated with worse survival.
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Ferroptosis in Cancer Cell Biology.
Christina M. Bebber,Fabienne Müller,Laura Prieto Clemente,Josephine Weber,Silvia von Karstedt +4 more
TL;DR: Current findings on cell biology relevant to ferroptosis in cancer are summarized and new conceptual avenues for utilising ferroPTosis in systemic treatment approaches for cancer are pointed out.
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Statistical Research on the Bioactivity of New Marine Natural Products Discovered during the 28 Years from 1985 to 2012
TL;DR: The statistics of bioactive compounds discovered from marine organisms from 1985 to 2012 are described based on the database, which contains information on more than 15,000 chemical substances including 4196 bioactive marine natural products.
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The interplay between macrophages and angiogenesis in development, tissue injury and regeneration
TL;DR: The role of macrophage in development, tissue injury and regeneration is reviewed, by focusing on the mechanisms used by subsets of these cells, such as the TIE2-expressing macrophages, to regulate angiogenesis and lymphangiogenesis in both fetal and post-natal life.
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Trial watch: Prognostic and predictive value of the immune infiltrate in cancer.
Laura Senovilla,Erika Vacchelli,Jérôme Galon,Sandy Adjemian,Alexander M.M. Eggermont,Wolf Hervé Fridman,Catherine Sautès-Fridman,Yuting Ma,Eric Tartour,Laurence Zitvogel,Guido Kroemer,Lorenzo Galluzzi +11 more
TL;DR: The results of clinical trials that have evaluated/are evaluating the prognostic and predictive value of the immune infiltrate in the context of solid malignancies are summarized.
References
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Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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Nuclear factor-kappaB in cancer development and progression.
TL;DR: This article showed that NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms.