Cancer-related inflammation.
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TLDR
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.Citations
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Journal ArticleDOI
Forcing form and function: biomechanical regulation of tumor evolution.
TL;DR: The biomechanical regulation of cell and tissue homeostasis from the molecular, cellular and tissue levels are discussed, including how modifications of this physical dialogue could contribute to cancer etiology.
Journal ArticleDOI
A Transcriptional Signature and Common Gene Networks Link Cancer with Lipid Metabolism and Diverse Human Diseases
Heather A. Hirsch,Dimitrios Iliopoulos,Amita A. Joshi,Yong Zhang,Savina Jaeger,Martha L. Bulyk,Martha L. Bulyk,Philip N. Tsichlis,X. Shirley Liu,Kevin Struhl +9 more
TL;DR: It is suggested that the interplay between this common transcriptional program and cell-type-specific factors gives rise to phenotypically disparate human diseases.
Journal ArticleDOI
The C-reactive protein/albumin ratio, a novel inflammation-based prognostic score, predicts outcomes in patients with hepatocellular carcinoma.
Akiyoshi Kinoshita,Hiroshi Onoda,Nami Imai,Akira Iwaku,Mutumi Oishi,Ken Tanaka,Nao Fushiya,Kazuhiko Koike,Hirokazu Nishino,Masato Matsushima +9 more
TL;DR: The CRP/Alb ratio might be an independent prognostic marker in patients with HCC, and may have comparable prognostic ability to other established inflammation-based prognostic scores.
Book ChapterDOI
Hypoxia-Inducible Factors as Essential Regulators of Inflammation
TL;DR: The role of each HIF isoform in myeloid cell function is dissected and their impact on acute and chronic inflammatory disorders is discussed, including the connection between inflammation and tumorigenesis.
Journal ArticleDOI
Neutrophils Suppress Intraluminal NK Cell–Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma Cells
Asaf Spiegel,Mary W. Brooks,Samin Houshyar,Ferenc Reinhardt,Michele Ardolino,Evelyn Fessler,Michelle B. Chen,Jordan A. Krall,Jasmine DeCock,Ioannis K. Zervantonakis,Alexandre Iannello,Yoshiko Iwamoto,Virna Cortez-Retamozo,Roger D. Kamm,Mikael J. Pittet,David H. Raulet,Robert A. Weinberg +16 more
TL;DR: In this article, the authors defined novel functions of neutrophils in promoting intraluminal survival and extravasation at sites of metastatic dissemination and showed that CD11b+/Ly6G+ neutrophILS enhance metastasis formation via two distinct mechanisms.
References
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Journal ArticleDOI
Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
Journal ArticleDOI
Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
Journal ArticleDOI
Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
Journal ArticleDOI
Nuclear factor-kappaB in cancer development and progression.
TL;DR: This article showed that NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms.