Cancer-related inflammation.
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TLDR
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.Citations
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Journal ArticleDOI
Colitis-associated cancer is dependent on the interplay between the hemostatic and inflammatory systems and supported by integrin αMβ2 engagement of fibrinogen
Kris A. Steinbrecher,Netanel A. Horowitz,Elizabeth A. Blevins,Kelley A. Barney,Maureen A. Shaw,Eleana Harmel-Laws,Fred D. Finkelman,Matthew J. Flick,Malinda D. Pinkerton,Kathryn E. Talmage,Keith W. Kombrinck,David P. Witte,Joseph S. Palumbo +12 more
TL;DR: It is suggested that therapies targeting fibrin(ogen)-alpha(M)beta(2) interactions may be useful in preventing and/or treating this important subset of malignancies.
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M1-like tumor-associated macrophages activated by exosome-transferred THBS1 promote malignant migration in oral squamous cell carcinoma
TL;DR: In this paper, the authors explored phenotypic alteration of macrophages during the development of oral squamous cell carcinoma (OSCC) using conditioned media (CM) and exosome supernatants.
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Fibrocytes represent a novel MDSC subset circulating in patients with metastatic cancer
Hua Zhang,Irena Maric,Michael DiPrima,Javed Khan,Rimas J. Orentas,Rosandra N. Kaplan,Crystal L. Mackall +6 more
TL;DR: A novel subset of cancer-induced myeloid-derived suppressor cells are described, which bear the phenotypic and functional hallmarks of fibrocytes but mediate immune suppression and may contribute to tumor progression via both immune evasion and angiogenesis.
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Epithelial-to-mesenchymal transition (EMT) induced by inflammatory priming elicits mesenchymal stromal cell-like immune-modulatory properties in cancer cells.
Mario Ricciardi,Marco Zanotto,Giorgio Malpeli,Giulio Bassi,Omar Perbellini,Marco Chilosi,Francesco Bifari,Mauro Krampera +7 more
TL;DR: EMT induced by inflammatory stimuli confers to cancer cells some mesenchymal stromal cell-like immune-modulatory properties, which could be a cue for cancer progression and metastatic dissemination by favouring immune escape.
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The pentraxins PTX3 and SAP in innate immunity, regulation of inflammation and tissue remodelling
Barbara Bottazzi,Antonio Inforzato,Massimo Messa,Marialuisa Barbagallo,Elena Magrini,Cecilia Garlanda,Alberto Mantovani +6 more
TL;DR: Pentraxins are a superfamily of fluid phase pattern recognition molecules conserved in evolution and characterized by a cyclic multimeric structure as discussed by the authors, and the long pentraxin 3 (PTX3) is the prototype of the long Pentraxin arm.
References
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Journal ArticleDOI
Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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Nuclear factor-kappaB in cancer development and progression.
TL;DR: This article showed that NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms.