Cancer-related inflammation.
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TLDR
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.Citations
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A Nonpeptidic Cathepsin S Activity-Based Probe for Noninvasive Optical Imaging of Tumor-Associated Macrophages
Martijn Verdoes,Laura E. Edgington,Ferenc A. Scheeren,Melissa J. Leyva,Galia Blum,Kipp Weiskopf,Michael Bachmann,Jonathan A. Ellman,Matthew Bogyo +8 more
TL;DR: The synthesis and characterization of a cathepsin S-directed, quenched activity-based probe (qABP), BMV083 is described, which makes use of an optimized nonpeptidic scaffold leading to enhanced in vivo properties relative to previously reported peptide-based probes.
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Tumour microenvironment responsive nanoconstructs for cancer theranostic
Arif Gulzar,Jiating Xu,Chen Wang,Fei He,Dan Yang,Shili Gai,Piaoping Yang,Jun Lin,Dayong Jin,Bengang Xing +9 more
TL;DR: The TME is discussed and the current advancement in several nano-formulations for cancer therapy, with an extraordinary stress on TME-responsive ones is summarized.
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Mechanisms that drive inflammatory tumor microenvironment, tumor heterogeneity, and metastatic progression
Li Yang,P. Charles Lin +1 more
TL;DR: This review summarizes recent progress, mechanistic understanding, and options for metastasis-targeted therapy.
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Microenvironment-Derived IL-1 and IL-17 Interact in the Control of Lung Metastasis
TL;DR: It is suggested that intervention in IL-1/IL-17 production could be therapeutically used to tilt this balance toward enhanced antitumor immunity in specific tumor microenvironments.
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Increased Dietary Vitamin D Suppresses MAPK Signaling, Colitis, and Colon Cancer
Stacey M Meeker,Audrey Seamons,Jisun Paik,Piper M. Treuting,Thea Brabb,William M. Grady,Lillian Maggio-Price +6 more
TL;DR: Increased dietary vitamin D is beneficial in preventing inflammation-associated colon cancer through suppression of inflammatory responses during initiation of neoplasia or early-stage carcinogenesis.
References
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Journal ArticleDOI
Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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Nuclear factor-kappaB in cancer development and progression.
TL;DR: This article showed that NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms.