Cancer-related inflammation.
TLDR
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.Citations
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Nomograms for predicting prognostic value of inflammatory biomarkers in colorectal cancer patients after radical resection
TL;DR: Nomograms based on OS and DFS can be recommended as practical models to evaluate prognosis for CRC patients, and Harrell's concordance index was adopted to evaluate prediction accuracy.
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The paracrine effect of cancer-associated fibroblast-induced interleukin-33 regulates the invasiveness of head and neck squamous cell carcinoma.
Su-Feng Chen,Su-Feng Chen,Shin Nieh,Shu-Wen Jao,Min-Zu Wu,Chia-Lin Liu,Yun-Ching Chang,Yaoh-Shiang Lin +7 more
TL;DR: Results indicate that CAFs promote cancer invasiveness via paracrine and autocrine effects on microenvironmental IL‐33 signalling, and suggest that IL‐ 33 is a potential prognostic biomarker that could be considered in therapeutic strategies for the treatment of patients with HNSCC.
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Lupeol and stigmasterol suppress tumor angiogenesis and inhibit cholangiocarcinoma growth in mice via downregulation of tumor necrosis factor-α.
Thaned Kangsamaksin,Supattra Chaithongyot,Chanida Wootthichairangsan,Rattanavinan Hanchaina,Chayada Tangshewinsirikul,Jisnuson Svasti,Jisnuson Svasti +6 more
TL;DR: The findings indicate that lupeol and stigmasterol effectively target tumor endothelial cells and suppress CCA tumor growth by their anti-inflammatory activities and are attractive candidates for anti-cancer treatment of CCA tumors.
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Chemoattractant Receptors BLT1 and CXCR3 Regulate Antitumor Immunity by Facilitating CD8+ T Cell Migration into Tumors.
TL;DR: A critical role is demonstrated for both BLT1 and CXCR3 in CTL migration to tumors and thus may be targeted to enhance efficacy of CTL-based immunotherapies.
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Up for Mischief? IL-17/Th17 in the tumour microenvironment
TL;DR: The role of interleukin (IL)-17 and the IL-17-producing T helper (Th)17 cells in cancer has recently become the focus of extensive investigation and the reciprocal interactions between Th17 cells and other cells of the immune system are outlined.
References
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Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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Nuclear factor-kappaB in cancer development and progression.
TL;DR: This article showed that NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms.