Cancer-related inflammation.
TLDR
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.Citations
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Paracrine and endocrine effects of adipose tissue on cancer development and progression
TL;DR: The role of adipocyte dysfunction associated with obesity and its potential impact on cancer biology is discussed.
NF-κB Signaling Pathway, Inflammation and Colorectal Cancer
TL;DR: It will be a long time before the coming of targeting NF-κB in CRC therapy, due to lack of knowledge about the specific roles of different NF-σB subunits in different stage of carcinogenesis, and compounds to block specific subunits of NF-ΩB family, it will beA long time until this factor is targeted in therapy.
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Inflammation and colorectal cancer.
TL;DR: The pathogenesis of IBD-related CRC is reviewed and the molecular mechanisms underlying the development of intestinal neoplasia in the setting of chronic inflammation are summarized.
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Vα24-invariant NKT cells mediate antitumor activity via killing of tumor-associated macrophages
Liping Song,Shahab Asgharzadeh,Jill Salo,Kelly Engell,Hong-Wei Wu,Richard Sposto,Tasnim Ara,Ayaka M. Silverman,Yves A. DeClerck,Robert C. Seeger,Leonid S. Metelitsa +10 more
TL;DR: It is demonstrated that CD68+ tumor-associated monocytes/macrophages (TAMs) represented the majority of CD1d-expressing cells in primary human neuroblastomas and killing of TAMs reveals what is believed to be a novel mechanism of NKT antitumor activity that relates to the disease outcome.
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Role of the Tumor Microenvironment in Breast Cancer.
TL;DR: This work focuses on the composition of the breast cancer microenvironment and concomitant molecular alterations, the specific interplay between various cell types and cancer cells, and the clinical implications of these findings.
References
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Journal ArticleDOI
Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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Nuclear factor-kappaB in cancer development and progression.
TL;DR: This article showed that NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms.