Cancer-related inflammation.
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TLDR
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.Citations
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Resolvin D1 binds human phagocytes with evidence for proresolving receptors
Sriram Krishnamoorthy,Antonio Recchiuti,Nan Chiang,Stephanie Yacoubian,Chih-Hao Lee,Rong Yang,Nicos A. Petasis,Charles N. Serhan +7 more
TL;DR: It is demonstrated that RvD1 actions on human polymorphonuclear leukocytes (PMNs) are pertussis toxin sensitive, decrease actin polymerization, and block LTB4-regulated adhesion molecules (β2 integrins).
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IL-4 induces cathepsin protease activity in tumor-associated macrophages to promote cancer growth and invasion
Vasilena Gocheva,Hao-Wei Wang,Bedrick B. Gadea,Tanaya Shree,Karen E. Hunter,Alfred L. Garfall,Tara Berman,Johanna A. Joyce +7 more
TL;DR: It is demonstrated that high levels of cathepsin protease activity are induced in the majority of macrophages in the microenvironment of pancreatic islet cancers, mammary tumors, and lung metastases during malignant progression and that interleukin-4 (IL-4) is responsible for inducing cat hepsin activity in macrophage in vitro and in vivo.
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Cancer: Inflaming metastasis.
TL;DR: Increasing evidence suggests that a seventh feature should make this list of hallmarks of cancer — inflammation.
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Cytokines in clinical cancer immunotherapy
Pedro Berraondo,Miguel F. Sanmamed,Maria C. Ochoa,Iñaki Etxeberria,Maria Angela Aznar,Jose Luis Perez-Gracia,Maria E. Rodriguez-Ruiz,Mariano Ponz-Sarvise,Eduardo Castanon,Ignacio Melero +9 more
TL;DR: The novel trends in the cytokine immunotherapy field that are yielding therapeutic agents for clinical trials are provided, including known molecules with novel mechanisms of action, new targets, and fusion proteins that increase half-life and target cytokine activity to the tumour microenvironment or to the desired effector immune cells.
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The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseases
Helena Tlaskalova-Hogenova,R. Štěpánková,Hana Kozakova,Tomas Hudcovic,Luca Vannucci,Ludmila Tučková,Pavel Rossmann,Tomáš Hrnčíř,Miloslav Kverka,Zuzana Jiraskova Zakostelska,Klara Klimesova,Jaroslava Přibylová,Jiřina Bártová,Daniel Sánchez,Petra Fundová,Dana Borovská,Dagmar Šrůtková,Zdeněk Zídek,Martin Schwarzer,Pavel Drastich,David P. Funda +20 more
TL;DR: Direct involvement of components of the microbiota in chronic intestinal inflammation and development of colonic neoplasia is demonstrated using models of human inflammatory bowel disease and colorectal carcinoma, and a protective effect of microbiota colonization was demonstrated for the development of autoimmune diabetes in non-obese diabetic (NOD) mice.
References
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Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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Nuclear factor-kappaB in cancer development and progression.
TL;DR: This article showed that NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms.