Cancer-related inflammation.
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TLDR
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.Citations
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Intratumoral neutrophils and plasmacytoid dendritic cells indicate poor prognosis and are associated with pSTAT3 expression in AJCC stage I/II melanoma.
Trine O. Jensen,Henrik Schmidt,Holger Jon Møller,Frede Donskov,Morten Høyer,Pia Sjoegren,Ib Jarle Christensen,Torben Steiniche +7 more
TL;DR: The prognostic impact of neutrophil and dendritic cell infiltration inPrimary melanoma and the association of this infiltration with activated STAT3 (pSTAT3) in primary melanoma cells are described.
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How platelets safeguard vascular integrity
TL;DR: It is proposed that modulating these newly described platelet functions may help treat haemorrhage as well as treat cancer by increasing the efficacy of drug delivery to tumours.
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Cancer therapy in the necroptosis era
TL;DR: Current studies surrounding this controversy on necroptosis-based antitumor research are summarized and the advantages, potential issues, and countermeasures of this novel therapy are discussed.
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Clinical promise of next-generation complement therapeutics.
TL;DR: An overview of the pathological roles of the complement system in acute and chronic disorders is provided, assessing recent developments in complement drug discovery, while highlighting the associated opportunities and challenges.
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Diabetes and cancer: two diseases with obesity as a common risk factor
TL;DR: The relationship between diabetes, obesity and cancer is examined, and the potential underlying causes of increased cancer risk in individuals with diabetes are investigated.
References
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Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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Nuclear factor-kappaB in cancer development and progression.
TL;DR: This article showed that NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms.