Cancer-related inflammation.
Reads0
Chats0
TLDR
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.Citations
More filters
Journal ArticleDOI
Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma.
Bo Hu,Xin-Rong Yang,Yang Xu,Yun-Fan Sun,Chao Sun,Wei Guo,Xin Zhang,Wei-Min Wang,Shuang-Jian Qiu,Jian Zhou,Jia Fan +10 more
TL;DR: The novel systemic immune-inflammation index (SII) based on lymphocyte, neutrophil, and platelet counts was a powerful prognostic indicator of poor outcome in patients with HCC and is a promising tool for HCC treatment strategy decisions.
Journal ArticleDOI
Systemic effects of local radiotherapy
TL;DR: Evidence indicates that radiotherapy recruits biological effectors outside the treatment field and has systemic effects, and the implications of such effects and the role of the immune system in standard cytotoxic treatments are discussed.
Journal ArticleDOI
Regulation of cell signalling by uPAR
TL;DR: Coordination of extracellular matrix (ECM) proteolysis and cell signalling by uPAR underlies its important function in cell migration, proliferation and survival and makes it an attractive therapeutic target in cancer and inflammatory diseases.
Journal ArticleDOI
miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice
Mark Boldin,Konstantin Taganov,Konstantin Taganov,Dinesh S. Rao,Dinesh S. Rao,Lili Yang,Jimmy L. Zhao,Manorama Kalwani,Yvette Garcia-Flores,Mui Luong,Asli Devrekanli,Jessica Xu,Guizhen Sun,Jia Tay,Peter S. Linsley,David Baltimore +15 more
TL;DR: Mice lacking miR-146a exhibit exaggerated inflammatory responses, autoimmunity, and increased rate of tumorigenesis.
Journal ArticleDOI
Linear ubiquitination prevents inflammation and regulates immune signalling
Björn Gerlach,Stefanie M. Cordier,Anna C. Schmukle,Christoph H. Emmerich,Christoph H. Emmerich,Eva Rieser,Tobias L. Haas,Andrew I. Webb,James A Rickard,Holly Anderton,W. Wei-Lynn Wong,Ueli Nachbur,Lahiru Gangoda,Uwe Warnken,Anthony W. Purcell,John Silke,Henning Walczak,Henning Walczak +17 more
TL;DR: It is concluded that by enabling linear ubiquitination in the TNF receptor signalling complex, SHARPIN interferes with TNF-induced cell death and, thereby, prevents inflammation.
References
More filters
Journal ArticleDOI
Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
Journal ArticleDOI
Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
Journal ArticleDOI
Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
Journal ArticleDOI
Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
Journal ArticleDOI
Nuclear factor-kappaB in cancer development and progression.
TL;DR: This article showed that NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms.