Cancer-related inflammation.
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TLDR
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.Citations
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Immunology in the clinic review series; focus on cancer: tumour-associated macrophages: undisputed stars of the inflammatory tumour microenvironment.
P. Allavena,Alberto Mantovani +1 more
TL;DR: This paper presents a meta-anatomy of the central nervous system and some of the mechanisms leading to anxiety, depression, and substance abuse that are known to occur after certain types of injuries.
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Cancer-associated fibroblasts and M2-polarized macrophages synergize during prostate carcinoma progression.
Giuseppina Comito,Elisa Giannoni,Coral Pons Segura,Pedro Barcellos-de-Souza,Maria Rosaria Raspollini,Gianna Baroni,Michele Lanciotti,Sergio Serni,Paola Chiarugi +8 more
TL;DR: It is demonstrated that stromal tumor-associated cells cooperate to favor malignancy of prostate carcinoma (PCa), and the analysis of patients affected by prostate cancers at different clinical stages revealed a clear increase in the M2/M1 ratio in correlation with clinical values.
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IKK/NF-κB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis
Julia Bollrath,Florian R. Greten +1 more
TL;DR: Genetic evidence is analysed indicating that the transcription factors nuclear factor‐κB and STAT3 have a central role in this context by regulating distinct functions in cancer cells and surrounding non‐tumorigenic cells.
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Pathobionts of the gastrointestinal microbiota and inflammatory disease
TL;DR: In this paper, the authors explore burgeoning hypotheses that the combination of an immunocompromised state with colonization by pathobionts together comprise a risk factor for certain inflammatory disorders and gastrointestinal (GI) cancer.
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VISTA Regulates the Development of Protective Antitumor Immunity.
Isabelle Le Mercier,Wenna Chen,Janet Louise Lines,Maria Day,Jiannan Li,Petra A. Sergent,Randolph J. Noelle,Li Wang +7 more
TL;DR: This study demonstrates the multiple mechanisms whereby VISTA relieves negative regulation by hematopoietic cells and enhances protective antitumor immunity and establishes a foundation for designing VISTA- targeted approaches either as a monotherapy or in combination with additional immune-targeted strategies for cancer immunotherapy.
References
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Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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Nuclear factor-kappaB in cancer development and progression.
TL;DR: This article showed that NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms.