Cancer-related inflammation.
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TLDR
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.Citations
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The Unfolded Protein Response in Immunogenic Cell Death and Cancer Immunotherapy
TL;DR: The relevance of therapy-mediated ER stress pathways in evoking ICD and how they could be used to optimize current immunotherapy approaches against cancer are reviewed.
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Prospective validation of a prognostic score for patients in immunotherapy phase I trials: The Gustave Roussy Immune Score (GRIm-Score)☆
Frédéric Bigot,Eduardo Castanon,Capucine Baldini,A. Hollebecque,Alberto Carmona,Sophie Postel-Vinay,Eric Angevin,Jean-Pierre Armand,Vincent Ribrag,Sandrine Aspeslagh,Andrea Varga,Rastislav Bahleda,Jessica Menis,Anas Gazzah,Jean-Marie Michot,Aurélien Marabelle,Jean-Charles Soria,Christophe Massard +17 more
TL;DR: Traditional prognostic variables included in the RMH score may be suboptimal to determine patient's prognosis in ICT phase I trials, and the Gustave Roussy Immune Score, based on albumin, LDH and NLR, allows a better selection of patients for ICT phases I trials.
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Intratumoral myeloid cells regulate responsiveness and resistance to antiangiogenic therapy.
Lee B. Rivera,David Meyronet,Valérie Hervieu,Mitchell J. Frederick,Emily K. Bergsland,Gabriele Bergers +5 more
TL;DR: It is found that the efficacy of angiogenic inhibitors targeting the VEGF/VEGFR pathway was dependent on induction of the angiostatic and immune-stimulatory chemokine CXCL14 in mouse models of pancreatic neuroendocrine and mammary tumors.
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Emergence of spatial structure in the tumor microenvironment due to the Warburg effect
Carlos Carmona-Fontaine,Vanni Bucci,Leila Akkari,Maxime Deforet,Johanna A. Joyce,Joao B. Xavier +5 more
TL;DR: It is shown that cancer cells are better adapted to metabolic changes in the microenvironment, leading to the emergence of spatial structure, which suggests that cancer metabolic changes create a microenvironment where tumor cells thrive over other cells.
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Soy and breast cancer: focus on angiogenesis.
TL;DR: A review of the antiangiogenic properties of soy isoflavonoids examines their possible underlying mechanisms and concludes that genistein possesses pleiotropic molecular mechanisms of action.
References
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Journal ArticleDOI
Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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Nuclear factor-kappaB in cancer development and progression.
TL;DR: This article showed that NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms.