Cancer-related inflammation.
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TLDR
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.Citations
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Impairment of CD4+ cytotoxic T cells predicts poor survival and high recurrence rates in patients with hepatocellular carcinoma.
Junliang Fu,Zheng Zhang,Lin Zhou,Zhaorui Qi,Shaojun Xing,Jiyun Lv,Jianfei Shi,Baoyun Fu,Zhenwen Liu,Ji-Yuan Zhang,Lei Jin,Yulai Zhao,George K. K. Lau,Jingmin Zhao,Fu-Sheng Wang +14 more
TL;DR: The progressive deficit in CD4+ CTLs induced by increased FoxP3+ regulatory T cells was correlated with poor survival and high recurrence rates in HCC patients, suggesting that CD4-CTLs may represent both a potential prognostic marker and a therapeutic target for the treatment of HCC.
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Pancreatic Cancer Cell Exosome-Mediated Macrophage Reprogramming and the Role of MicroRNAs 155 and 125b2 Transfection using Nanoparticle Delivery Systems
TL;DR: The results show that upon successful transfection of Panc-1 cells, the exosome content was altered leading to differential communication and reprogramming of the J774.A1 cells to an M1 phenotype, which may be very promising for cancer therapy.
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Inflammation, DNA methylation and colitis-associated cancer
Lori Hartnett,Laurence J. Egan +1 more
TL;DR: Recently, epigenetic alterations, in particular alterations in DNA methylation, have been observed during inflammation and inflammation-associated carcinogenesis and the therapeutic potential of understanding these molecular mechanisms is highlighted.
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The biology of personalized cancer medicine: Facing individual complexities underlying hallmark capabilities
Michele De Palma,Douglas Hanahan +1 more
TL;DR: Considerations, metrics, and methods that may prove instrumental in charting the landscape of evaluating individual tumors so to better inform diagnosis, prognosis, and therapy are highlighted.
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Systemic Correlates of White Adipose Tissue Inflammation in Early-Stage Breast Cancer
Neil M. Iyengar,Neil M. Iyengar,Xi Kathy Zhou,Ayca Gucalp,Ayca Gucalp,Patrick G. Morris,Louise R. Howe,Dilip Giri,Monica Morrow,Hanhan Wang,Michael Pollak,Lee W. Jones,Lee W. Jones,Clifford A. Hudis,Clifford A. Hudis,Andrew J. Dannenberg +15 more
TL;DR: WAT inflammation, a clinically occult process, helps to explain the relationship between metabolic syndrome and worse breast cancer prognosis.
References
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Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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Nuclear factor-kappaB in cancer development and progression.
TL;DR: This article showed that NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms.