Cancer-related inflammation.
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TLDR
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.Citations
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High mammographic density is associated with an increase in stromal collagen and immune cells within the mammary epithelium
Cecilia W. Huo,G. L. Chew,Prue Hill,Dexing Huang,Wendy V. Ingman,Leigh J. Hodson,Kristy A. Brown,Astrid Magenau,Astrid Magenau,Amr H. Allam,Amr H. Allam,Ewan J. McGhee,Paul Timpson,Paul Timpson,Michael A. Henderson,Michael A. Henderson,Erik W. Thompson,Erik W. Thompson,Kara L. Britt,Kara L. Britt +19 more
TL;DR: In this paper, the authors assessed the histological and immunohistochemical differences between matched HMD and low mammographic density (LMD) breast tissues from healthy women to define which cell features may mediate the increased MD and MD-associated BC risk.
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Identification and validation of SAA as a potential lung cancer biomarker and its involvement in metastatic pathogenesis of lung cancer.
Hye-Jin Sung,Jung-Mo Ahn,Yeon-Hee Yoon,Taiyoun Rhim,Choon-Sik Park,Jae Yong Park,Soo-Youn Lee,Jong-Won Kim,Je-Yoel Cho +8 more
TL;DR: The data suggest that a higher concentration of SAA can serve as an indicator of lung adenocarcinoma and represents a therapeutic target for the inhibition of lung cancer metastasis.
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The role of reactive oxygen species (ROS) and cytochrome P-450 2E1 in the generation of carcinogenic etheno-DNA adducts.
TL;DR: In patients with non-alcoholic steatohepatitis (NASH) hepatic etheno-DNA adducts do not correlate with CYP2E1 indicating that in NASH etheni-DNAAdducts formation is predominately driven by inflammation rather than by CYP1E1 induction, it is strongly believed that they are involved in ethanol mediated carcinogenesis.
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Sialoadhesin - a macrophage-restricted marker of immunoregulation and inflammation
TL;DR: This review presents Sn as a macrophage‐specific marker of inflammation and immunoregulation with the potential to becoming an important biomarker for immunologically active macrophages and a target for therapy.
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Periodontal disease, edentulism, and pancreatic cancer: a meta-analysis.
TL;DR: Using meta-analysis, both periodontitis and edentulism appear to be associated with PC, even after adjusting for common risk factors.
References
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Journal ArticleDOI
Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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Nuclear factor-kappaB in cancer development and progression.
TL;DR: This article showed that NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms.