Cancer-related inflammation.
Reads0
Chats0
TLDR
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.Citations
More filters
Journal ArticleDOI
IL-1β promotes stemness and invasiveness of colon cancer cells through Zeb1 activation
TL;DR: The findings indicate that IL-1β may promote colon tumor growth and invasion through activation of CSC self-renewal and EMT, and Zeb1 plays a critical role in these two processes.
Journal ArticleDOI
Epithelial-Mesenchymal Transition: General Principles and Pathological Relevance with Special Emphasis on the Role of Matrix Metalloproteinases
TL;DR: How EMT functions in normal development, how it could be activated in pathologic conditions-especially by matrix metalloproteinases-and how it may be targeted for therapeutic benefit are outlined.
Journal ArticleDOI
Childhood obesity: increased risk for cardiometabolic disease and cancer in adulthood.
TL;DR: Current understanding of epidemiology, underlying factors, concomitant disease, as well as available intervention strategies are summarized and an overview of what has been reached so far and what measures should be undertaken to counteract the obesogenic environment is given.
Journal ArticleDOI
Tumor Promotion via Injury- and Death-Induced Inflammation
TL;DR: A resolution to this paradox based on cell death-mediated induction of tumor promoting inflammatory cytokines, which enhance cell survival and trigger compensatory proliferation in response to tissue injury is discussed.
Journal ArticleDOI
Dietary Advanced Glycation End Products and Their Role in Health and Disease
Jaime Uribarri,María Dolores del Castillo,María Pía de la Maza,Rosana Filip,Alejandro Gugliucci,Claudia Luevano-Contreras,Maciste H. Macías-Cervantes,Deborah Helena Markowicz Bastos,Alejandra Medrano,Teresita Menini,Manuel Portero-Otin,Armando Rojas,Geni Rodrigues Sampaio,Kazimierz Wrobel,Katarzyna Wrobel,Ma. Eugenia Garay-Sevilla +15 more
TL;DR: This review illustrates currently known facts about dietary AGEs as well as pointing out areas that require further research.
References
More filters
Journal ArticleDOI
Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
Journal ArticleDOI
Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
Journal ArticleDOI
Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
Journal ArticleDOI
Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
Journal ArticleDOI
Nuclear factor-kappaB in cancer development and progression.
TL;DR: This article showed that NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms.