Cancer-related inflammation.
TLDR
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.Citations
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Rationale and Means to Target Pro-Inflammatory Interleukin-8 (CXCL8) Signaling in Cancer
TL;DR: Reports of pre-clinical cancer studies and clinical trials using CXCL8-CXCR1/2-targeting strategies for the treatment of inflammatory diseases and the future translational opportunities for use of such agents in oncology will be discussed.
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Plasma Fibrinogen Levels and Prognosis in Patients with Ovarian Cancer: A Multicenter Study
Stephan Polterauer,Christoph Grimm,Veronika Seebacher,Nicole Concin,Christian Marth,Caroline Tomovski,Heinrich Husslein,Heinz Leipold,Katrin Hefler-Frischmuth,Clemens B. Tempfer,Alexander Reinthaller,Lukas A. Hefler +11 more
TL;DR: Pretherapeutic plasma fibrinogen levels can be used as an independent prognostic parameter in patients with EOC and were correlated with clinicopathological parameters and patient survival.
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The Role of Pre-Existing Diabetes Mellitus on Hepatocellular Carcinoma Occurrence and Prognosis: A Meta-Analysis of Prospective Cohort Studies
TL;DR: The findings from the current meta-analysis suggest that DM may be both associated with elevated risks of both HCC incidence and mortality and HCC patients with pre-existing diabetes have a poorer prognosis relative to their non-diabetic counterparts.
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Vitamin D and breast cancer: inhibition of estrogen synthesis and signaling.
TL;DR: It is hypothesize that the inhibition of estrogen synthesis and signaling by calcitriol and its anti-inflammatory actions will play an important role in the use of calcriol for the prevention and/or treatment of BCa.
Journal Article
Role of tumour-associated macrophages in cancer-related inflammation.
TL;DR: The evidence for the functional reprogramming of TAM during the course of tumor progression and the molecular mechanisms that regulate such event are discussed and the implications for anti-cancer therapies aimed at prompting TAM to mount an effective antitumor response are discussed.
References
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Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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Nuclear factor-kappaB in cancer development and progression.
TL;DR: This article showed that NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms.