Cancer-related inflammation.
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TLDR
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.Citations
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Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
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Immunity, Inflammation, and Cancer
TL;DR: The principal mechanisms that govern the effects of inflammation and immunity on tumor development are outlined and attractive new targets for cancer therapy and prevention are discussed.
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Macrophage plasticity and polarization: in vivo veritas
Antonio Sica,Alberto Mantovani +1 more
TL;DR: The identification of mechanisms and molecules associated with macrophage plasticity and polarized activation provides a basis for Macrophage-centered diagnostic and therapeutic strategies.
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Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines
Peter J. Murray,Judith E. Allen,Subhra K. Biswas,Edward A. Fisher,Derek W. Gilroy,Sergij Goerdt,Siamon Gordon,John A. Hamilton,Lionel B. Ivashkiv,Toby Lawrence,Massimo Locati,Alberto Mantovani,Fernando O. Martinez,Jean-Louis Mege,David M. Mosser,Gioacchino Natoli,Jeroen P. J. Saeij,Joachim L. Schultze,Kari Ann Shirey,Antonio Sica,Jill Suttles,Irina A. Udalova,Jo A. Van Ginderachter,Stefanie N. Vogel,Thomas A. Wynn +24 more
TL;DR: A set of standards encompassing three principles-the source of macrophages, definition of the activators, and a consensus collection of markers to describe macrophage activation are described with the goal of unifying experimental standards for diverse experimental scenarios.
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Macrophage Diversity Enhances Tumor Progression and Metastasis
Bin-Zhi Qian,Jeffrey W. Pollard +1 more
TL;DR: There is persuasive clinical and experimental evidence that macrophages promote cancer initiation and malignant progression, and specialized subpopulations of macrophage may represent important new therapeutic targets.
References
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Tumour necrosis factor α: a potential target for the therapy of solid tumours
TL;DR: There is convincing evidence that under specific conditions TNFalpha is a tumour promoter and helps to produce the toxic effects associated with conventional cancer therapy, such as the cytokine release syndrome and cisplatin-induced nephrotoxicity.
Journal Article
Ovarian cancer cells polarize macrophages towards a tumor-associated phenotype
Thorsten Hagemann,Julia L. Wilson,Frances Burke,Hagen Kulbe,N F Li,Annette Plüddemann,Kellie A. Charles,Siamon Gordon,Frances R. Balkwill +8 more
TL;DR: It is demonstrated that ovarian cancer cells switch cocultured macrophages to a phenotype similar to that found in ovarian tumors, and TNF-α was key to SR-A induction via its p75 receptor.
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Epidermal Growth Factor and Hypoxia-induced Expression of CXC Chemokine Receptor 4 on Non-small Cell Lung Cancer Cells Is Regulated by the Phosphatidylinositol 3-Kinase/PTEN/AKT/Mammalian Target of Rapamycin Signaling Pathway and Activation of Hypoxia Inducible Factor-1α *
Roderick J. Phillips,Javier Mestas,Mehrnaz Gharaee-Kermani,Marie D. Burdick,Antonio Sica,John A. Belperio,Michael P. Keane,Robert M. Strieter +7 more
TL;DR: A combination of low oxygen tension and overexpression of EGFR within the primary tumor of NSCLC may provide the microenvironmental signals necessary to upregulate CXCR4 expression and promote metastasis.
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Increased survival, proliferation, and migration in metastatic human pancreatic tumor cells expressing functional CXCR4.
Federica Marchesi,Paolo Monti,Biagio Eugenio Leone,Alessandro Zerbi,Annunciata Vecchi,Lorenzo Piemonti,Alberto Mantovani,Paola Allavena +7 more
TL;DR: The results indicate that the CXCR4 receptor is frequently expressed in metastatic pancreatic tumor cells, and not only stimulates cell motility and invasion but also promotes survival and proliferation.
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Tumor necrosis factor-alpha stimulates the epithelial-to-mesenchymal transition of human colonic organoids.
TL;DR: A novel role for the stroma is established in influencing EMT in colon carcinoma, and a selective advantage is identified to the stromal presence of infiltrating leukocytes in regulating malignant tumor progression.