Cancer-related inflammation.
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TLDR
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.Citations
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Journal ArticleDOI
Inflammatory Signals Induce AT2 Cell-Derived Damage-Associated Transient Progenitors that Mediate Alveolar Regeneration.
Jinwook Choi,Jong-Eun Park,Georgia Tsagkogeorga,Motoko Yanagita,Bon-Kyoung Koo,Namshik Han,Joo-Hyeon Lee +6 more
TL;DR: It is found that interstitial macrophage-derived IL-1β primes a subset of AT2 cells expressing Il1r1 for conversion into DATPs via a HIF1α-mediated glycolysis pathway, which is required for mature AT1 cell differentiation.
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The neutrophil-to-lymphocyte ratio: a narrative review
Sara Socorro Faria,Paulo César Fernandes,Marcelo José Barbosa Silva,Vladmir Cláudio Cordeiro de Lima,Wagner Fontes,Ruffo Freitas-Junior,Agda Karina Eterovic,Patrice Forget +7 more
TL;DR: The possibilities and limitations of using the neutrophil-to-lymphocyte ratio as a clinical tool for risk stratification helpful for individual treatment of breast cancer patients are addressed.
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Anti-inflammatory treatments for chronic diseases: a review.
Durgaprasad Laveti,Manoj Kumar,Rajkumar Hemalatha,Ramakrishna Sistla,Vasant Naidu,Venu Talla,Vinod Verma,Navrinder Kaur,Ravinder Nagpal +8 more
TL;DR: It is explored and summarized that how some drugs and natural compounds show their modulatory activity in inflammatory pathways and chronic inflammatory markers in these inflammatory diseases.
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Resveratrol decreases the levels of miR-155 by upregulating miR-663, a microRNA targeting JunB and JunD.
Esmerina Tili,Jean-Jacques Michaille,Jean-Jacques Michaille,Brett Adair,Hansjuerg Alder,Emeric Limagne,Cristian Taccioli,Manuela Ferracin,Dominique Delmas,Norbert Latruffe,Carlo M. Croce +10 more
TL;DR: It is established that, in human THP-1 monocytic cells as well as in human blood monocytes, resveratrol upregulates miR-663, a microRNA potentially targeting multiple genes implicated in the immune response, and that the effects of resver atrol on both AP-1 activity and JunB levels are dose dependent.
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Heat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an update
TL;DR: The extensive work that has been carried out and is still in progress aimed at understanding the oncogenic mechanisms by which HSP genes are switched on, determining the roles of HSF 1/HSP in malignant transformation and discovering approaches to therapy based on disrupting the influence of the HSF1-controlled transcriptome in cancer are reviewed.
References
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Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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Nuclear factor-kappaB in cancer development and progression.
TL;DR: This article showed that NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms.