Cancer-related inflammation.
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TLDR
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.Citations
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Lymphocyte-C-reactive Protein Ratio as Promising New Marker for Predicting Surgical and Oncological Outcomes in Colorectal Cancer.
Yoshinaga Okugawa,Yuji Toiyama,Akira Yamamoto,Tsunehiko Shigemori,Shozo Ide,Takahito Kitajima,Hiroyuki Fujikawa,Hiromi Yasuda,Junichiro Hiro,Shigeyuki Yoshiyama,Takeshi Yokoe,Susumu Saigusa,Koji Tanaka,Yumiko Shirai,Minako Kobayashi,Masaki Ohi,Toshimitsu Araki,Donald C. McMillan,Chikao Miki,Ajay Goel,Masato Kusunoki +20 more
TL;DR: It is identified that a combination of lymphocytic counts along with CRP levels, which is defined as LCR, is a more reliable indicator of poor prognosis compared with other combinations of inflammatory markers, in CRC patients.
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Drosophila melanogaster: A Model Organism to Study Cancer.
Zhasmine Mirzoyan,Manuela Sollazzo,Mariateresa Allocca,Alice Valenza,Daniela Grifoni,Paola Bellosta +5 more
TL;DR: The basic mechanisms and signaling pathways conserved between humans and flies responsible of inducing uncontrolled growth and cancer development are outlined and used to identify signals driving growth cell autonomously and within organs, drug discovery and for therapeutic approaches.
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The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses.
Inga Bauer,Alessia Grozio,Denise Lasigliè,Giovanna Basile,Laura Sturla,Mirko Magnone,Giovanna Sociali,Debora Soncini,Irene Caffa,Alessandro Poggi,Gabriele Zoppoli,Michele Cea,Michele Cea,Georg Feldmann,Raul Mostoslavsky,Alberto Ballestrero,Franco Patrone,Santina Bruzzone,Alessio Nencioni +18 more
TL;DR: It is shown that SIRT6 enhances the expression of pro-inflammatory cyto-/chemokines, such as IL8 and TNF, and promotes cell migration in pancreatic cancer cells by enhancing Ca2+ responses.
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Inflammaging and Cancer: A Challenge for the Mediterranean Diet
Rita Ostan,Catia Lanzarini,Elisa Pini,Maria Scurti,Dario Vianello,Claudia Bertarelli,Cristina Fabbri,Massimo Izzi,Giustina Palmas,Fiammetta Biondi,Morena Martucci,Elena Bellavista,Stefano Salvioli,Miriam Capri,Claudio Franceschi,Aurelia Santoro +15 more
TL;DR: Data indicating that the Mediterranean Diet modulates multiple interconnected processes involved in carcinogenesis and inflammatory response such as free radical production, NF-κB activation and expression of inflammatory mediators, and the eicosanoids pathway are reviewed.
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Tumor-Activated Monocytes Promote Expansion of IL-17–Producing CD8+ T Cells in Hepatocellular Carcinoma Patients
Dong-Ming Kuang,Chen Peng,Qiyi Zhao,Yan Wu,Ling-Yan Zhu,Jianen Wang,Xiao-Yu Yin,Lian Li,Limin Zheng +8 more
TL;DR: It is shown that Tc17 cells constitute a remarkable portion of IL-17–producing cells in human HCC, and it is found that tumor-activated monocytes secreted a set of key cytokines to trigger the proliferation of Tc 17 cells.
References
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Journal ArticleDOI
Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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Nuclear factor-kappaB in cancer development and progression.
TL;DR: This article showed that NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms.