Cancer-related inflammation.
Reads0
Chats0
TLDR
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.Citations
More filters
Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
Immunity, Inflammation, and Cancer
TL;DR: The principal mechanisms that govern the effects of inflammation and immunity on tumor development are outlined and attractive new targets for cancer therapy and prevention are discussed.
Journal ArticleDOI
Macrophage plasticity and polarization: in vivo veritas
Antonio Sica,Alberto Mantovani +1 more
TL;DR: The identification of mechanisms and molecules associated with macrophage plasticity and polarized activation provides a basis for Macrophage-centered diagnostic and therapeutic strategies.
Journal ArticleDOI
Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines
Peter J. Murray,Judith E. Allen,Subhra K. Biswas,Edward A. Fisher,Derek W. Gilroy,Sergij Goerdt,Siamon Gordon,John A. Hamilton,Lionel B. Ivashkiv,Toby Lawrence,Massimo Locati,Alberto Mantovani,Fernando O. Martinez,Jean-Louis Mege,David M. Mosser,Gioacchino Natoli,Jeroen P. J. Saeij,Joachim L. Schultze,Kari Ann Shirey,Antonio Sica,Jill Suttles,Irina A. Udalova,Jo A. Van Ginderachter,Stefanie N. Vogel,Thomas A. Wynn +24 more
TL;DR: A set of standards encompassing three principles-the source of macrophages, definition of the activators, and a consensus collection of markers to describe macrophage activation are described with the goal of unifying experimental standards for diverse experimental scenarios.
Journal ArticleDOI
Macrophage Diversity Enhances Tumor Progression and Metastasis
Bin-Zhi Qian,Jeffrey W. Pollard +1 more
TL;DR: There is persuasive clinical and experimental evidence that macrophages promote cancer initiation and malignant progression, and specialized subpopulations of macrophage may represent important new therapeutic targets.
References
More filters
Journal ArticleDOI
Bv8 regulates myeloid-cell-dependent tumour angiogenesis
Farbod Shojaei,Xiumin Wu,Cuiling Zhong,Lanlan Yu,Xiao-Huan Liang,Jenny Yao,Dominique Blanchard,Carlos Bais,Franklin Peale,Nicholas van Bruggen,Calvin Ho,Jed Ross,Martha Tan,Richard A.D. Carano,Y. Gloria Meng,Napoleone Ferrara +15 more
TL;DR: Bv8 modulates mobilization of CD11b+Gr1+ cells from the bone marrow during tumour development and also promotes angiogenesis locally, which is additive to those of anti-Vegf antibodies or cytotoxic chemotherapy.
Journal ArticleDOI
NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia.
Maya Dajee,Mirella Lazarov,Jennifer Y. Zhang,Ti Cai,Cheryl L. Green,Alan J. Russell,M. Peter Marinkovich,Shiying Tao,Qun Lin,Yoshiaki Kubo,Paul A. Khavari +10 more
TL;DR: It is shown that in normal human epidermal cells both NF-κB and oncogenic Ras trigger cell-cycle arrest, and IκBα circumvents restraints on growth promotion induced by oncogens Ras and can act with Ras to induce invasive human tissue neoplasia.
Journal ArticleDOI
Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling.
Jacqueline D. Shields,Mark E. Fleury,Carolyn Yong,Alice A. Tomei,Gwendalyn J. Randolph,Melody A. Swartz +5 more
TL;DR: Computational modeling revealed that transcellular gradients of CCR7 ligand were created under flow to drive this response, illustrating how tumor cells may be guided to lymphatics during metastasis.
Journal ArticleDOI
Mast cells are required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors
Laura Soucek,Elizabeth R. Lawlor,Elizabeth R. Lawlor,Darya Soto,Ksenya Shchors,Lamorna Brown Swigart,Gerard I. Evan +6 more
TL;DR: It is shown in a β-cell tumor model that activation of Myc in vivo triggers rapid recruitment of mast cells to the tumor site—a recruitment that is absolutely required for macroscopic tumor expansion.
Journal ArticleDOI
Mutations in the NF-kappaB signaling pathway: implications for human disease.
G Courtois,Thomas D. Gilmore +1 more
TL;DR: This review describes human diseases in which mutations in the components of the core NF-κB signaling pathway have been implicated and discusses the molecular mechanisms by which these alterations in NF-σB signaling are likely to contribute to the disease pathology.