Cancer-related inflammation.
TLDR
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.Citations
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The role of vitamin D in cancer prevention and treatment.
TL;DR: The clinical trials evaluating the use of calcitriol and its analogues in the treatment of patients with cancer are described and the reasons for the lack of impressive beneficial effects in clinical trials compared with the substantial efficacy seen in preclinical models are discussed.
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Beyond proteases: Basement membrane mechanics and cancer invasion
Julie Chang,Ovijit Chaudhuri +1 more
TL;DR: Chang and Chaudhuri discuss basement membrane mechanics and how cells use both proteolytic and physical mechanisms to invade basement membranes during cancer progression.
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Reduced cell proliferation by IKK2 depletion in a mouse lung-cancer model
Yifeng Xia,Narayana Yeddula,Mathias Leblanc,Eugene Ke,Eugene Ke,Yonghui Zhang,Eric Oldfield,Reuben J. Shaw,Inder M. Verma +8 more
TL;DR: A lentiviral-vector-mediated mouse model enables generation of non-small-cell lung cancer from less than 100 alveolar epithelial cells, and the role of IKK2 and NF-κB in lung-cancer development is investigated, suggesting the possible application of Ikk2 and Timp-1 inhibitors in treating lung cancer.
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B cell-regulated immune responses in tumor models and cancer patients
TL;DR: Recent evidence on the interactions between B and T cells in murine models and cancer patients and their implications for cancer immunology are reviewed.
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Stress-inducible gene Atf3 in the noncancer host cells contributes to chemotherapy-exacerbated breast cancer metastasis.
TL;DR: The ability of paclitaxel (PTX) to exacerbate metastasis in mouse models of breast cancer is described, demonstrating that, despite the apparent benefit of reducing tumor size, PTX increased the circulating tumor cells in the blood and enhanced the metastatic burden at the lung.
References
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Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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Nuclear factor-kappaB in cancer development and progression.
TL;DR: This article showed that NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms.