Cancer-related inflammation.
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TLDR
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.Citations
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Markers of systemic inflammation predict survival in patients with advanced renal cell cancer
TL;DR: Markers of systemic inflammation contribute significantly to prognostic classification in addition to established factors for pre-treated patients with advanced RCC, and stratification of patients using these markers in future clinical trials is recommended.
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Coffee and cancer risk, epidemiological evidence, and molecular mechanisms.
TL;DR: The epidemiological evidence consistently indicates that coffee protects against liver cancer, and also point toward protective effects for risk of colorectal cancers, and the experimental evidence for effects of coffee and coffee constituents on each of these processes is discussed.
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Ageing: from inflammation to cancer.
Giulia Costanza Leonardi,Giulia Accardi,Roberto Monastero,Ferdinando Nicoletti,Massimo Libra +4 more
TL;DR: The molecular and cellular pathway involved in age-related chronic inflammation along with its potential triggers and their connection with cancer development are reviewed.
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Tumor Microenvironment, a Paradigm in Hepatocellular Carcinoma Progression and Therapy
TL;DR: The study of the involved molecular mechanisms can open a new insight to define more effective treatment strategies, and the principal challenges that are relevant to controlling this milieu are highlighted.
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Mesenchymal Cells in Colon Cancer
TL;DR: The intestinal mesenchymal cell-specific pathways that regulate these processes are reviewed, with a focus on their roles in mediating interactions between inflammation and carcinogenesis.
References
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Journal ArticleDOI
Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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Nuclear factor-kappaB in cancer development and progression.
TL;DR: This article showed that NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms.