Cancer-related inflammation.
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TLDR
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.Citations
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Neutrophils Suppress Intraluminal NK Cell-Mediated Tumor Cell Clearance and Enhance Extravasation of Disseminated Carcinoma Cells
Mary W. Brooks,Michele Ardolino,E. Fessler,Jordan A. Krall,J. DeCock,Alexandre Iannello,Yoshiko Iwamoto,Virna Cortez-Retamozo,Mikael J. Pittet,David H. Raulet,Asaf Spiegel,Samin Houshyar,Ferenc Reinhardt,Michelle B. Chen,Ioannis K. Zervantonakis,Roger D. Kamm,Robert A. Weinberg +16 more
TL;DR: Neutrophils are identified as key regulators of intraluminal survival and extravasation through their cross-talk with host cells and disseminating carcinoma cells through the secretion of IL1β and matrix metalloproteinases.
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The Role of Chemokines in Wound Healing.
TL;DR: The therapeutic potential of targeting chemokines as a novel approach to overcome the debilitating effects of impaired wound healing is explored.
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The prognostic value of preoperative NLR, d-NLR, PLR and LMR for predicting clinical outcome in surgical colorectal cancer patients
Houqun Ying,Houqun Ying,Qiwen Deng,Bangshun He,Yuqin Pan,Feng Wang,Huiling Sun,Huiling Sun,Jie Chen,Jie Chen,Xian Liu,Shukui Wang,Shukui Wang +12 more
TL;DR: It is shown that preoperative elevated NLR can be considered as an independent prognostic biomarker for RFS, OS and CSS, and Nomograms containing NLR provide improved accuracy for predicting clinical outcomes in surgical CRC patients under surgery resection.
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Metabolic origins of spatial organization in the tumor microenvironment
Carlos Carmona-Fontaine,Carlos Carmona-Fontaine,Maxime Deforet,Leila Akkari,Leila Akkari,Craig B. Thompson,Johanna A. Joyce,Johanna A. Joyce,Joao B. Xavier +8 more
TL;DR: It is proposed that gradients of extracellular metabolites act as tumor morphogens that impose order within the microenvironment, much like signaling molecules convey positional information to organize embryonic tissues.
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Induction of autophagy is essential for monocyte-macrophage differentiation
TL;DR: It is found that the differentiation signal releases Beclin1 from Bcl-2 by activating JNK and blocks Atg5 cleavage, both of which are critical for the induction of autophagy, which results in apoptosis of cells that are engaged in differentiation.
References
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Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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Nuclear factor-kappaB in cancer development and progression.
TL;DR: This article showed that NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms.