Cancer-related inflammation.
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TLDR
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.Citations
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Alterations in the microbiota drive interleukin-17c production from intestinal epithelial cells to promote tumorigenesis
Xinyang Song,Gao Hanchao,Yingying Lin,Yikun Yao,Shu Zhu,Jingjing Wang,Yan Liu,Xiaomin Yao,Guangxun Meng,Nan Shen,Yufang Shi,Yoichiro Iwakura,Youcun Qian +12 more
TL;DR: In this article, the authors found that the innate-like cytokine IL-17C was upregulated in human colorectal cancers and in mouse intestinal tumor models by the microbiota.
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Assessing Cell and Organ Senescence Biomarkers
TL;DR: This work focuses on the current methods to assess cellular senescence, discriminating the advantages and disadvantages of severalsenescence biomarkers.
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Investigating the causal relationship of C-reactive protein with 32 complex somatic and psychiatric outcomes: a large-scale cross-consortium Mendelian randomization study
Bram P. Prins,Bram P. Prins,Ali Abbasi,Ali Abbasi,Anson Wong,Ahmad Vaez,Ahmad Vaez,Ilja M. Nolte,Nora Franceschini,Philip E. Stuart,Javier Guterriez Achury,Vanisha Mistry,Vanisha Mistry,Jonathan P. Bradfield,Ana M. Valdes,Jose Bras,Aleksey Shatunov,Chen Lu,Buhm Han,Soumya Raychaudhuri,Steve Bevan,Maureen D. Mayes,Lam C. Tsoi,Evangelos Evangelou,Evangelos Evangelou,Rajan P. Nair,Struan F.A. Grant,Struan F.A. Grant,Constantin Polychronakos,Timothy R D J Radstake,David A. van Heel,Melanie L. Dunstan,Nicholas W. Wood,Ammar Al-Chalabi,Ammar Al-Chalabi,Abbas Dehghan,Hakon Hakonarson,Hakon Hakonarson,Hugh S. Markus,James T. Elder,Jo Knight,Dan E. Arking,Tim D. Spector,Bobby P. C. Koeleman,Cornelia M. van Duijn,Javier Martín,Andrew P. Morris,Andrew P. Morris,Rinse K. Weersma,Cisca Wijmenga,Patricia B. Munroe,John R. B. Perry,Jennie G. Pouget,Jennie G. Pouget,Yalda Jamshidi,Harold Snieder,Behrooz Z. Alizadeh +56 more
TL;DR: C-reactive protein GRSGWAS showed a statistically significant protective relationship of a 10% genetically elevated CRP level with the risk of schizophrenia and a standardized CRP polygenic risk score (CRPPRS) at p-value thresholds showed a protective effect against schizophrenia.
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Neutrophils: important contributors to tumor progression and metastasis
Agnieszka Swierczak,Agnieszka Swierczak,Kellie A. Mouchemore,Kellie A. Mouchemore,John A. Hamilton,Robin L. Anderson,Robin L. Anderson +6 more
TL;DR: This review will focus on the data demonstrating a role for neutrophils in both tumor growth and metastasis and will attempt to clarify the discrepancies in the literature.
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Expression and clinical significance of apolipoprotein E in pancreatic ductal adenocarcinoma
Jiong Chen,Long-jiang Chen,Ren-bao Yang,Yun-lian Xia,Hang-cheng Zhou,Wen Wu,Yin Lu,Liwei Hu,Yue Zhao +8 more
TL;DR: The results suggest that ApoE may be a potential PDAC-related biomarker and alone or in combination with other markers may provide additional information for the diagnosis and clinical management of PDAC.
References
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Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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Nuclear factor-kappaB in cancer development and progression.
TL;DR: This article showed that NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms.