Cancer-related inflammation.
TLDR
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.Citations
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Pretreatment neutrophil-to-lymphocyte ratio as an independent predictor of recurrence in patients with nonmetastatic renal cell carcinoma.
TL;DR: The combination of T stage and the neutrophil-to-lymphocyte ratio can be used to stratify recurrence risk in patients with nonmetastatic renal cell carcinoma.
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A derived neutrophil to lymphocyte ratio predicts clinical outcome in stage II and III colon cancer patients
Gudrun Absenger,Joanna Szkandera,Martin Pichler,Michael Stotz,F Arminger,Melanie Weissmueller,Renate Schaberl-Moser,Hellmut Samonigg,Tatjana Stojakovic,Armin Gerger +9 more
TL;DR: The dNLR may be an independent prognostic marker for TTR and OS in patients with stage II and III colon cancer in patients included in this retrospective study.
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Our perception of the mast cell from Paul Ehrlich to now.
TL;DR: This once enigmatic cell of Paul Ehrlich has proved to be both adaptable and multifunctional.
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Metabolic changes in tumor cells and tumor-associated macrophages: A mutual relationship.
TL;DR: Understanding the metabolic changes governing the intricate relationship between the tumor cells and the TAMs represents an essential step towards developing novel therapeutic approaches targeting the metabolic reprogramming of the immune cells to potentiate their tumoricidal potential and to circumvent therapy resistance.
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Macrophages, Inflammation, and Lung Cancer.
Emma M. Conway,Larissa A. Pikor,Sonia H. Y. Kung,Melisa J. Hamilton,Stephen Lam,Wan L. Lam,Kevin L. Bennewith +6 more
TL;DR: This work discusses the contribution of macrophages to an intrinsic pathway, driven by genetic alterations that lead to neoplasia and inflammation, and an extrinsic pathway,driven by inflammatory conditions that increase cancer risk.
References
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Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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Nuclear factor-kappaB in cancer development and progression.
TL;DR: This article showed that NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms.