Cancer-related inflammation.
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TLDR
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.Citations
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Comparison of the prognostic values of various inflammation based factors in patients with pancreatic cancer
De Shen Wang,Hui Yan Luo,Miao Zhen Qiu,Zhi Qiang Wang,Dong Sheng Zhang,Feng Hua Wang,Yu Hong Li,Rui-Hua Xu +7 more
TL;DR: Elevated NLR is superior to the mGPS, PI, PLR and PNI for prognostication in patients with pancreatic cancer, and is associated with higher white cell count, higher PLR, elevated CRP, hypoalbuminemia, increased mG PS, PI and P NI.
Journal ArticleDOI
Harnessing tumor-associated macrophages as aids for cancer immunotherapy
TL;DR: The mechanisms by which macrophages become immunosuppressive and compromise antitumor immunity are reviewed, and initial TAMs-targeting strategies have shown efficacy across therapeutic modalities and tumor types in both preclinical and clinical studies.
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Topography of cancer-associated immune cells in human solid tumors
Jakob Nikolas Kather,Meggy Suarez-Carmona,Meggy Suarez-Carmona,Pornpimol Charoentong,Pornpimol Charoentong,Cleo-Aron Weis,Daniela Hirsch,Peter Bankhead,Marcel Horning,Dyke Ferber,Dyke Ferber,Ivan Kel,Esther Herpel,Sarah Schott,Inka Zörnig,Inka Zörnig,Jochen Utikal,Jochen Utikal,Alexander Marx,Timo Gaiser,H Brenner,Jenny Chang-Claude,Jenny Chang-Claude,Michael Hoffmeister,Dirk Jäger,Dirk Jäger,Niels Halama,Niels Halama +27 more
TL;DR: It is shown that hot, cold and excluded topographies for effector lymphocytes (CD8) and tumor-associated macrophages (CD163) alone are not prognostic, but that a bivariate classification system can stratify patients.
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Inflammation-mediated promotion of invasion and metastasis
TL;DR: Evidence indicating that inflammatory mediators affect genetic stability and cause persistent epigenetic alterations suggests that inflammatory components of the tumor microenvironment impacts on fundamental mechanisms responsible for the generation of metastatic variants.
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Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer
Heinz Läubli,Oliver M. T. Pearce,Flavio Schwarz,Shoib S. Siddiqui,Lingquan Deng,Michal A. Stanczak,Liwen Deng,Andrea Verhagen,Patrick Secrest,Chrissy Lusk,Ann G. Schwartz,Nissi Varki,Jack D. Bui,Ajit Varki +13 more
TL;DR: A previously unidentified impact of inhibitory myelomonocytic Siglecs in cancer biology is defined, with distinct roles that reflect the dual function of myelmonocytic cells in cancer progression.
References
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Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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Nuclear factor-kappaB in cancer development and progression.
TL;DR: This article showed that NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms.