Cancer-related inflammation.
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TLDR
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.Citations
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Journal ArticleDOI
The immune contexture of primary and metastatic human tumours
Nicolas A. Giraldo,Etienne Becht,Etienne Becht,Etienne Becht,Romain Remark,Romain Remark,Romain Remark,Diane Damotte,Catherine Sautès-Fridman,Catherine Sautès-Fridman,Catherine Sautès-Fridman,Wolf H. Fridman,Wolf H. Fridman,Wolf H. Fridman +13 more
TL;DR: This model highlights a novel tumour cell-dependent immune contexture that predicts patient's clinical outcome and has implications in the use of immunotherapies.
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CD5 Binds to Interleukin-6 and Induces a Feed-Forward Loop with the Transcription Factor STAT3 in B Cells to Promote Cancer
Chunyan Zhang,Hong Xin,Wang Zhang,Paul J. Yazaki,Zhifang Zhang,Keith Le,Wenzhao Li,Heehyoung Lee,Larry W. Kwak,Stephen J. Forman,Richard Jove,Hua Yu +11 more
TL;DR: It is demonstrated that the proportion of CD5(+) relative to interleukin-6 receptor α (IL-6Rα)-expressing B cells was greatly increased in tumors and showed activation of STAT3 in multiple types of human tumor tissues.
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The Role of Chronic Inflammation in Obesity-Associated Cancers
TL;DR: The connection between the different factors that can lead to the chronic inflammatory state in the obese individual, as well as their effect in tumorigenesis, is addressed and the association between obesity, inflammation, and esophageal, liver, colon, postmenopausal breast, and endometrial cancers is discussed.
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Dietary phytochemicals in breast cancer research: anticancer effects and potential utility for effective chemoprevention
Andrea Kapinová,Peter Kubatka,Olga Golubnitschaja,Martin Kello,Pavol Zubor,Peter Solár,Martin Péč +6 more
TL;DR: Abundant evidence has been collected for beneficial effects of flavonoids, carotenoids, phenolic acids, and organosulfur compounds affecting a number of cancer-related pathways, and phytochemicals may positively affect processes of cell signaling, cell cycle regulation, oxidative stress response, and inflammation.
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Quality of Life in Patients With Advanced Cancer: Differential Association With Performance Status and Systemic Inflammatory Response
Barry Laird,Marie Fallon,Marianne Jensen Hjermstad,Sharon Tuck,Stein Kaasa,Pål Klepstad,Donald C. McMillan +6 more
TL;DR: Examination of the relationship between quality of life parameters, performance status (PS), and the systemic inflammatory response in patients with advanced cancer found systemic inflammation was associated with quality-of-life parameters independent of PS.
References
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Journal ArticleDOI
Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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Nuclear factor-kappaB in cancer development and progression.
TL;DR: This article showed that NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms.