Cancer-related inflammation.
TLDR
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.Citations
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CCR2-Dependent Recruitment of Macrophages by Tumor-Educated Mesenchymal Stromal Cells Promotes Tumor Development and Is Mimicked by TNFα
Guangwen Ren,Guangwen Ren,Xin Zhao,Ying Wang,Xin Zhang,Xiaodong Chen,Chunliang Xu,Zeng Rong Yuan,Arthur I. Roberts,Liying Zhang,Betty Zheng,Ting Wen,Yanyan Han,Arnold B. Rabson,Jay A. Tischfield,Changshun Shao,Changshun Shao,Yufang Shi,Yufang Shi +18 more
TL;DR: It is demonstrated that, in an inflammatory environment, tumor-resident MSCs promote tumor growth by recruiting monocytes/macrophages.
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NFκB signaling in carcinogenesis and as a potential molecular target for cancer therapy
Han-Ming Shen,Vinay Tergaonkar +1 more
TL;DR: This review of the literature documenting the involvement of NFκB in cancer is summarized, and the approaches that are being undertaken to developNFκB inhibitors towards treatment of human cancers are focused on.
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SUMO and the robustness of cancer
TL;DR: The role of sumoylation in tumorigenesis is examined as a possibly necessary safeguard that protects the stability and functionality of otherwise easily misregulated gene expression programmes and signalling pathways of cancer cells.
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Perspectives and opportunities for nanomedicine in the management of atherosclerosis (vol 10, pg 835, 2011)
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Exploring vitamin D metabolism and function in cancer
Sang-Min Jeon,Eun-Ae Shin +1 more
TL;DR: The metabolic processes underlying the anti-cancer effects of vitamin D are summarized, ways to improve vitamin D-based therapies for cancer are discussed, and ideas to improve these therapies are discussed.
References
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Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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Nuclear factor-kappaB in cancer development and progression.
TL;DR: This article showed that NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms.