Cancer-related inflammation.
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TLDR
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.Citations
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Autophagy and disease: always two sides to a problem
TL;DR: This review focuses on several pathological conditions associated with primary or secondary defects in autophagy and comment on a recurring theme for many of them, ie the fact thatAutophagy can often exert both beneficial and aggravating effects on the progression of disease.
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The role of interleukin-1 in general pathology
TL;DR: A look back on the definition of “inflammation” in traditional general pathology and new insights into interleukin-1 are discussed in view of its history and the molecular bases of diseases, as well as current progress in therapeutics.
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Oxidative stress promotes myofibroblast differentiation and tumour spreading.
Aurore Toullec,Damien Gerald,Gilles Despouy,Brigitte Bourachot,Melissa Cardon,Sylvain Lefort,Marion Richardson,Guillem Rigaill,Maria Carla Parrini,Maria Carla Parrini,Carlo Lucchesi,Carlo Lucchesi,Dorine Bellanger,Marc-Henri Stern,Thierry Dubois,Xavier Sastre-Garau,Olivier Delattre,Anne Vincent-Salomon,Fatima Mechta-Grigoriou +18 more
TL;DR: A new mechanism by which oxidative stress increases the migratory properties of stromal fibroblasts, which in turn potentiate tumour dissemination is uncovered, uncovering the relevance of the findings in human cancers.
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Complement in cancer: untangling an intricate relationship.
TL;DR: This Review summarizes the current understanding of complement-mediated effector functions in the tumour microenvironment and offers insight into clinical aspects, including the feasibility of using complement biomarkers for cancer diagnosis and the use of complement inhibitors during cancer treatment.
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Cancer Immunosurveillance by Tissue-Resident Innate Lymphoid Cells and Innate-like T Cells
Saïda Dadi,Sagar Chhangawala,Sagar Chhangawala,Benjamin M. Whitlock,Benjamin M. Whitlock,Ruth A. Franklin,Ruth A. Franklin,Chong T. Luo,Soyoung Oh,Ahmed Toure,Yuri Pritykin,Morgan Huse,Christina S. Leslie,Ming O. Li +13 more
TL;DR: It is shown that cell transformation triggers a tissue-resident lymphocyte response in oncogene-induced murine cancer models, revealing a tumor-elicited immunosurveillance mechanism that engages unconventional type-1-like innate lymphoid cells and type 1 innate-like T cells.
References
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Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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Nuclear factor-kappaB in cancer development and progression.
TL;DR: This article showed that NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms.