Cancer-related inflammation.
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TLDR
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.Citations
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Molecular targets of celastrol derived from Thunder of God Vine: Potential role in the treatment of inflammatory disorders and cancer
TL;DR: Celastrol's ability to modulate the expression of pro-inflammatory cytokines, MHC II, HO-1, iNOS, NF-κB, Notch- 1, AKT/mTOR, CXCR4, TRAIL receptors DR4 and DR5, CHOP, JNK, VEGF, adhesion molecules, proteasome activity, potassium channels, and heat shock response has been reported.
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An evolutionary perspective on field cancerization.
TL;DR: The evidence of field cancerization across organs is reviewed, the biological mechanisms that drive the evolutionary process that results in field creation are examined and how measurements of the cancerized field could improve cancer risk prediction in patients with pre-malignant disease are discussed.
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PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer
Eduardo Bonavita,Stefania Gentile,Marcello Rubino,Virginia Maina,Roberto Papait,Paolo Kunderfranco,Carolina M. Greco,F. Feruglio,Martina Molgora,Ilaria Laface,Silvia Tartari,Andrea Doni,Fabio Pasqualini,Elisa Barbati,Gianluca Basso,Maria Rosaria Galdiero,Manuela Nebuloni,Massimo Roncalli,Piergiuseppe Colombo,Luigi Laghi,John D. Lambris,Sébastien Jaillon,Cecilia Garlanda,Alberto Mantovani +23 more
TL;DR: PTX3, an effector molecule belonging to the humoral arm of innate immunity, acts as an extrinsic oncosuppressor gene in mouse and man by regulating Complement-dependent, macrophage-sustained, tumor-promoting inflammation.
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Tumor-associated Macrophages (TAM) and Inflammation in Colorectal Cancer
TL;DR: The characterization of the most relevant inflammatory pathways in CRC is instrumental for the identification of new target molecules that could lead to improved diagnosis and treatment.
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In vivo biosensing via tissue-localizable near-infrared-fluorescent single-walled carbon nanotubes
Nicole M. Iverson,Paul W. Barone,Mia Shandell,Laura J. Trudel,Selda Sen,Selda Sen,Fatih Şen,Fatih Şen,Vsevolod Ivanov,Esha Atolia,Edgardo Farias,Thomas P. McNicholas,Nigel F. Reuel,Nicola Parry,Gerald N. Wogan,Michael S. Strano +15 more
TL;DR: It is demonstrated that a polyethylene glycol ligated copolymer stabilizes near infrared fluorescent SWNT sensors in solution, enabling intravenous injection into mice and the selective detection of local nitric oxide concentration with a detection limit of 1 μM.
References
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Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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Nuclear factor-kappaB in cancer development and progression.
TL;DR: This article showed that NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms.