Cancer-related inflammation.
Reads0
Chats0
TLDR
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.Citations
More filters
Journal ArticleDOI
Hallmarks of cancer: the next generation.
TL;DR: Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer.
Journal ArticleDOI
Immunity, Inflammation, and Cancer
TL;DR: The principal mechanisms that govern the effects of inflammation and immunity on tumor development are outlined and attractive new targets for cancer therapy and prevention are discussed.
Journal ArticleDOI
Macrophage plasticity and polarization: in vivo veritas
Antonio Sica,Alberto Mantovani +1 more
TL;DR: The identification of mechanisms and molecules associated with macrophage plasticity and polarized activation provides a basis for Macrophage-centered diagnostic and therapeutic strategies.
Journal ArticleDOI
Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines
Peter J. Murray,Judith E. Allen,Subhra K. Biswas,Edward A. Fisher,Derek W. Gilroy,Sergij Goerdt,Siamon Gordon,John A. Hamilton,Lionel B. Ivashkiv,Toby Lawrence,Massimo Locati,Alberto Mantovani,Fernando O. Martinez,Jean-Louis Mege,David M. Mosser,Gioacchino Natoli,Jeroen P. J. Saeij,Joachim L. Schultze,Kari Ann Shirey,Antonio Sica,Jill Suttles,Irina A. Udalova,Jo A. Van Ginderachter,Stefanie N. Vogel,Thomas A. Wynn +24 more
TL;DR: A set of standards encompassing three principles-the source of macrophages, definition of the activators, and a consensus collection of markers to describe macrophage activation are described with the goal of unifying experimental standards for diverse experimental scenarios.
Journal ArticleDOI
Macrophage Diversity Enhances Tumor Progression and Metastasis
Bin-Zhi Qian,Jeffrey W. Pollard +1 more
TL;DR: There is persuasive clinical and experimental evidence that macrophages promote cancer initiation and malignant progression, and specialized subpopulations of macrophage may represent important new therapeutic targets.
References
More filters
Journal ArticleDOI
CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment.
TL;DR: Observations reveal that CXCR4 is an important molecule involved in the spread and progression of a variety of different tumors, and that CxCR4 antagonists, although initially developed for treatment of AIDS, actually may become effective agents for the treatment of neoplastic disease.
Journal ArticleDOI
IKKβ Couples Hepatocyte Death to Cytokine-Driven Compensatory Proliferation that Promotes Chemical Hepatocarcinogenesis
TL;DR: IKKbeta orchestrates inflammatory crosstalk between hepatocytes and hematopoietic-derived cells that promotes chemical hepatocarcinogenesis and blocks excessive DEN-induced carcinogenesis in Ikkbeta(Deltahep) mice.
Journal ArticleDOI
Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells.
Tianhong Wang,Guilian Niu,Marcin Kortylewski,Lyudmila Burdelya,Kenneth H. Shain,Shumin M. Zhang,Raka Bhattacharya,Dmitry I. Gabrilovich,Richard Heller,Domenico Coppola,William S. Dalton,Richard Jove,Drew M. Pardoll,Hua Yu +13 more
TL;DR: It is proposed that tumor Stat-3 activity can mediate immune evasion by blocking both the production and sensing of inflammatory signals by multiple components of the immune system.
Journal ArticleDOI
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice.
Carmen Guerra,Alberto J. Schuhmacher,Marta Cañamero,Paul J. Grippo,Lena Verdaguer,Lucía Pérez-Gallego,Pierre Dubus,Eric P. Sandgren,Mariano Barbacid +8 more
TL;DR: It is reported that selective expression of an endogenous K-Ras(G12V) oncogene in embryonic cells of acinar/centroacinar lineage results in pancreatic intraepithelial neoplasias (PanINs) and invasive PDA, suggesting that PDA originates by differentiation of acINs or their precursors into ductal-like cells.
Journal ArticleDOI
The origin and function of tumor-associated macrophages
TL;DR: This delicate balance between tumor-associated macrophages and neoplastic cells may be considered to have a symbiotic relationship and the prospects for its therapeutic manipulation are described.