Cancer-related inflammation.
TLDR
The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.Citations
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Chronotherapy and the molecular clock: Clinical implications in oncology
TL;DR: It is important to take circadian timing into account at all stages of new drug development in an effort to optimize the therapeutic index for new cancer drugs.
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Cancer associated fibroblasts express pro-inflammatory factors in human breast and ovarian tumors.
TL;DR: It is shown that CAFs in human breast and ovarian tumors express high levels of the pro- inflammatory factors IL-6, COX-2 and CXCL1, previously identified to be part of a CAF pro-inflammatory gene signature, and that NF-κB is up-regulated in breast and ovary CAFs.
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The lymphocyte/monocyte ratio predicts poor clinical outcome and improves the predictive accuracy in patients with soft tissue sarcomas
Joanna Szkandera,Armin Gerger,Bernadette Liegl-Atzwanger,Gudrun Absenger,Michael Stotz,Joerg Friesenbichler,Slave Trajanoski,Tatjana Stojakovic,Katharina Eberhard,Andreas Leithner,Martin Pichler +10 more
TL;DR: The pre‐operative L/M ratio represents a novel independent prognostic factor for prediction the clinical outcome in STS patients for the first time and might be helpful in improved individual risk assessment.
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Podoplanin-Positive Fibroblasts Enhance Lung Adenocarcinoma Tumor Formation: Podoplanin in Fibroblast Functions for Tumor Progression
Ayuko Hoshino,Genichiro Ishii,Takashi Ito,Kazuhiko Aoyagi,Yoichi Ohtaki,Kanji Nagai,Hiroki Sasaki,Atsushi Ochiai +7 more
TL;DR: Results indicate a promotive effect of hVAFs mediated by podoplanin on cancer progression and suggest that the perivascular environment may constitute a specific niche for tumor progression.
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Mast Cells: Potential Positive and Negative Roles in Tumor Biology
TL;DR: Basic features of mast cell biology are reviewed with a special emphasis on those relevant to their potential roles in tumors, and how using in vivo tumor models in combination with models in which mast cell function can be modulated has implicated mast cells in the regulation of host responses to tumors are discussed.
References
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Inflammation and cancer
Lisa M. Coussens,Zena Werb +1 more
TL;DR: It is now becoming clear that the tumour microenvironment, which is largely orchestrated by inflammatory cells, is an indispensable participant in the neoplastic process, fostering proliferation, survival and migration.
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Inflammation and cancer: back to Virchow?
TL;DR: A rationale for the use of cytokine and chemokine blockade, and further investigation of non-steroidal anti-inflammatory drugs, in the chemoprevention and treatment of malignant diseases is provided.
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Involvement of chemokine receptors in breast cancer metastasis.
Anja Müller,Bernhard Homey,Hortensia Soto,Nianfeng Ge,Daniel Catron,Matthew E. Buchanan,Terri McClanahan,Erin Murphy,Wei Yuan,Stephan N. Wagner,Jose Luis Barrera,Alejandro Mohar,Emma Verastegui,Albert Zlotnik +13 more
TL;DR: It is reported that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumours and metastases and their respective ligands CXCL12/SDF-1α and CCL21/6Ckine exhibit peak levels of expression in organs representing the first destinations of breast cancer metastasis.
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Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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Nuclear factor-kappaB in cancer development and progression.
TL;DR: This article showed that NF-kappaB provides a mechanistic link between inflammation and cancer, and is a major factor controlling the ability of both pre-neoplastic and malignant cells to resist apoptosis-based tumour-surveillance mechanisms.