Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics Consortium
Wouter J. Peyrot,Van der Auwera S,Y. Milaneschi,Conor V. Dolan,Madden Paf.,Patrick F. Sullivan,Jana Strohmaier,Stephan Ripke,M. Rietschel,Michel G. Nivard,Niamh Mullins,Grant W. Montgomery,Anjali K. Henders,A. C. Heat,Helen L. Fisher,Erin C. Dunn,Enda M. Byrne,T. A. Air,Bernhard T. Baune,Gerome Breen,Douglas F. Levinson,Cathryn M. Lewis,Nicholas G. Martin,E. N. Nelson,Dorret I. Boomsma,Hans J. Grabe,Naomi R. Wray,Penninx Bwjh. +27 more
TLDR
In this paper, the meta-analytic evidence for interaction between major depressive disorder (MDD) and childhood trauma (CT) was found, which suggests that the previously reported interaction effects, although both statistically significant, can best be interpreted as chance findings.About:
This article is published in Biological Psychiatry.The article was published on 2018-07-15 and is currently open access. It has received 95 citations till now. The article focuses on the topics: Child abuse & Major depressive disorder.read more
Citations
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Journal ArticleDOI
Polygenic risk scores: from research tools to clinical instruments
TL;DR: How polygenic risk score may be informative at different points in the disease trajectory is considered giving examples of progress in the field and discussing obstacles that need to be addressed before clinical implementation.
Journal ArticleDOI
The Devastating Clinical Consequences of Child Abuse and Neglect: Increased Disease Vulnerability and Poor Treatment Response in Mood Disorders
TL;DR: The persistent alterations associated with childhood maltreatment are summarized, including alterations in the hypothalamic-pituitary-adrenal axis and inflammatory cytokines, which may contribute to disease vulnerability and a more pernicious disease course.
Journal ArticleDOI
Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank
Coleman Jri,Wouter J. Peyrot,Kirstin L. Purves,Davis Kas.,Christopher Rayner,Shing Wan Choi,Christopher Hübel,Helena Gaspar,Carol Kan,Van der Auwera S,Mark Adams,Donald M. Lyall,Karmel W. Choi,Erin C. Dunn,Evangelos Vassos,Andrea Danese,Barbara Maughan,Hans J. Grabe,Cathryn M. Lewis,Paul F. O'Reilly,Andrew M. McIntosh,Daniel J. Smith,Naomi R. Wray,Matthew Hotopf,Thalia C. Eley,Gerome Breen +25 more
TL;DR: The results suggest that the genetic contribution to MDD is greater when reported trauma is present, and that a complex relationship exists between reported trauma exposure, body composition, and MDD.
Journal ArticleDOI
Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls
Erik Pettersson,Paul Lichtenstein,Henrik Larsson,Henrik Larsson,Jie Song,Arpana Agrawal,Anders D. Børglum,Cynthia M. Bulik,Cynthia M. Bulik,Mark J. Daly,Mark J. Daly,Lea K. Davis,Ditte Demontis,Howard J. Edenberg,Jakob Grove,Joel Gelernter,Joel Gelernter,Benjamin M. Neale,Benjamin M. Neale,Antonio F. Pardiñas,E Stahl,James T.R. Walters,Raymond K. Walters,Raymond K. Walters,Patrick F. Sullivan,Patrick F. Sullivan,Danielle Posthuma,Tinca J. C. Polderman +27 more
TL;DR: Given the unique character of each study design, the convergent findings for these eight psychiatric conditions suggest that heritability estimates are robust across different methods, and highlight large differences in genetic and environmental influences between psychiatric disorders.
Journal ArticleDOI
Reviewing the genetics of heterogeneity in depression: operationalizations, manifestations and etiologies.
TL;DR: Recent efforts to identify depression subtypes using clinical and data-driven approaches are reviewed, differences in genetic architecture of depression across contexts are examined, and it is argued that heterogeneity in operationalizations of depression is likely a considerable source of inconsistency.
References
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Gonçalo R. Abecasis,David Altshuler,David Altshuler,Adam Auton,Lisa D Brooks,Richard Durbin,Richard A. Gibbs,Matthew E. Hurles,Gil McVean +8 more
TL;DR: The 1000 Genomes Project aims to provide a deep characterization of human genome sequence variation as a foundation for investigating the relationship between genotype and phenotype as mentioned in this paper, and the results of the pilot phase of the project, designed to develop and compare different strategies for genomewide sequencing with high-throughput platforms.
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Influence of Life Stress on Depression: Moderation by a Polymorphism in the 5-HTT Gene
Avshalom Caspi,Karen Sugden,Terrie E. Moffitt,Alan Taylor,Ian W. Craig,Hona Lee Harrington,Joseph L. McClay,Jonathan Mill,Judy Martin,Antony W. Braithwaite,Richie Poulton +10 more
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TL;DR: The second-generation versions of PLINK will offer dramatic improvements in performance and compatibility, and for the first time, users without access to high-end computing resources can perform several essential analyses of the feature-rich and very large genetic datasets coming into use.
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