Journal ArticleDOI
Evolutionary dynamics of natural product biosynthesis in bacteria
Marc G. Chevrette,Karina Gutiérrez-García,Nelly Selem-Mojica,César Aguilar-Martínez,Alan Yañez-Olvera,Hilda E. Ramos-Aboites,Paul A. Hoskisson,Francisco Barona-Gómez +7 more
TLDR
In this article, a review of known evolutionary mechanisms underlying the overwhelming chemical diversity of bacterial secondary metabolism, focusing on enzyme promiscuity and the evolution of enzymatic domains that enable metabolic traits is presented.About:
This article is published in Natural Product Reports.The article was published on 2020-04-29. It has received 83 citations till now. The article focuses on the topics: Evolutionary dynamics & Fitness landscape.read more
Citations
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Population Genomics of Early Events in the Ecological Differentiation of Bacteria
B. J. Shapiro,Jonathan Friedman,Otto X. Cordero,Sarah P. Preheim,Sonia Timberlake,Gitta Szabó,Martin F. Polz,Eric J. Alm +7 more
TL;DR: This paper showed that in two recently diverged populations of ocean bacteria, ecological differentiation has occurred akin to a sexual mechanism: a few genome regions have swept through subpopulations in a habitat-specific manner, accompanied by gradual separation of gene pools as evidenced by increased habitat specificity of the most recent recombinations.
A Systematic Computational Analysis of Biosynthetic Gene Cluster Evolution: Lessons for Engineering Biosynthesis - eScholarship
Andrej Sali,Michael A. Fischbach,Marnix H. Medema,Peter Cimermancic,Eriko Takano,MA Fischbach +5 more
TL;DR: By performing a systematic computational analysis of BGC evolution, this work derives evidence for three findings that shed light on the ways in which, despite these constraints, nature successfully invents new molecules.
Journal ArticleDOI
Mining genomes to illuminate the specialized chemistry of life
TL;DR: The rapid accumulation of genomic information has revealed that the metabolic capacity of virtually all organisms is vastly underappreciated as discussed by the authors, and genome mining technologies are accelerating metabolite discovery in all organisms, including protists, plants and animals.
Journal ArticleDOI
cblaster: a remote search tool for rapid identification and visualization of homologous gene clusters
Posted ContentDOI
cblaster: a remote search tool for rapid identification and visualisation of homologous gene clusters
TL;DR: Cblaster as discussed by the authors is a Python-based tool to detect collocated genes in local and remote databases, which can be easily incorporated into larger bio-informatic pipelines and is easy to use, offering both a command line and a user-friendly graphical user interface.
References
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Origins and Evolution of Antibiotic Resistance
Julian Davies,Dorothy Davies +1 more
TL;DR: A review of antibiotic resistance development over the past half-century can be found in this article, with the oft-restated conclusion that it is time to act and to restore the therapeutic applications of antibiotics.
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Sharing and community curation of mass spectrometry data with Global Natural Products Social Molecular Networking
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TL;DR: In GNPS, crowdsourced curation of freely available community-wide reference MS libraries will underpin improved annotations and data-driven social-networking should facilitate identification of spectra and foster collaborations.
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The Comprehensive Antibiotic Resistance Database
Andrew G. McArthur,Nicholas Waglechner,Fazmin Nizam,Austin Yan,Marisa A. Azad,Alison J. Baylay,Kirandeep Bhullar,Marc J. Canova,Gianfranco De Pascale,Linda Ejim,Lindsay Kalan,Andrew M. King,Kalinka Koteva,Mariya Morar,Michael R. Mulvey,Jonathan S O'Brien,Andrew C. Pawlowski,Laura J. V. Piddock,Peter Spanogiannopoulos,Arlene D. Sutherland,Irene Tang,Patricia L. Taylor,Maulik N. Thaker,Wenliang Wang,Marie Yan,Tennison Yu,Gerard D. Wright +26 more
TL;DR: The CARD integrates disparate molecular and sequence data, provides a unique organizing principle in the form of the Antibiotic Resistance Ontology (ARO), and can quickly identify putative antibiotic resistance genes in new unannotated genome sequences.
Journal ArticleDOI
The distribution of fitness effects of new mutations
TL;DR: The distribution of fitness effects (DFE) of new mutations is a fundamental entity in genetics that has implications ranging from the genetic basis of complex disease to the stability of the molecular clock.
Journal ArticleDOI
Chemistry and biology of siderophores.
Robert C. Hider,Xiaole Kong +1 more
TL;DR: The classification and chemical properties of siderophores are described, before outlining research on sidersophore biosynthesis and transport and Clinically important siderophile design and the therapeutic potential are described.
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