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Journal ArticleDOI

Expression, purification, immunogenicity and protective efficacy of a recombinant nucleoside hydrolase from Leishmania donovani, a vaccine candidate for preventing cutaneous leishmaniasis

C. Patrick McAtee, +13 more
- 01 Feb 2017 - 
- Vol. 130, pp 129-136
TLDR
Mice immunized with the LdNH36 antigen in combination with the GLA-SE adjuvant and challenged with Leishmania mexicana showed significant reductions in parasite burden, confirming the protective efficacy of this vaccine candidate.
About: 
This article is published in Protein Expression and Purification.The article was published on 2017-02-01. It has received 11 citations till now. The article focuses on the topics: Leishmania mexicana & Leishmania donovani.

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Mangiferin alleviates renal inflammatory injury in spontaneously hypertensive rats by inhibiting MCP-1/CCR2 signaling pathway

Xiaoqin Hu, +6 more
- 01 Mar 2023 - 
TL;DR: In this article , the effects of Mangiferin (MGF) on renal inflammatory injury in spontaneously hypertensive rats (SHRs) were investigated, and the results showed that the levels of interleukin 6 (IL-6), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and recombinant chemokine C-C-Motif receptor 2 (CCR2) were increased in SHRs, meanwhile, the level of IL-10 was decreased in SHR.
References
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Journal ArticleDOI

Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013

Mohsen Naghavi, +731 more
- 10 Jan 2015 - 
TL;DR: In the Global Burden of Disease Study 2013 (GBD 2013) as discussed by the authors, the authors used the GBD 2010 methods with some refinements to improve accuracy applied to an updated database of vital registration, survey, and census data.
Journal ArticleDOI

Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013

Theo Vos, +689 more
- 22 Aug 2015 - 
TL;DR: In the Global Burden of Disease Study 2013 (GBD 2013) as mentioned in this paper, the authors estimated the quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013.
Journal ArticleDOI

The global burden of disease study 2010: interpretation and implications for the neglected tropical diseases.

Peter J. Hotez, +33 more
- 24 Jul 2014 - 
TL;DR: The publication of the Global Burden of Disease Study 2010 and the accompanying collection of Lancet articles in December 2012 provided the most comprehensive attempt to quantify the burden of almost 300 diseases, injuries, and risk factors, including neglected tropical diseases (NTDs).
Journal ArticleDOI

Quantitative proteomic analysis by accurate mass retention time pairs.

Jeffrey C. Silva, +10 more
- 02 Mar 2005 - 
TL;DR: The principal focus of this paper will demonstrate the quantitative aspects of the methodology and continue with a discussion of the associated, complementary qualitative capabilities.
Journal ArticleDOI

Database searching and accounting of multiplexed precursor and product ion spectra from the data independent analysis of simple and complex peptide mixtures

Guo-Zhong Li, +6 more
- 01 Mar 2009 - 
TL;DR: A novel database search algorithm is presented for the qualitative identification of proteins over a wide dynamic range, both in simple and complex biological samples, providing approximately 20% more protein identifications, compared to a more conventional data directed approach using the same identification criteria.
Related Papers (5)

From mouse to man: safety, immunogenicity and efficacy of a candidate leishmaniasis vaccine LEISH-F3+GLA-SE.

Rhea N. Coler, +19 more
- 01 Apr 2015 - 

Human and Murine Immune Responses to a Novel Leishmania major Recombinant Protein Encoded by Members of a Multicopy Gene Family

John R. Webb, +8 more
- 01 Jul 1998 - 

Leishmania major: Production of recombinant gp63, its antigenicity and immunogenicity in mice

Emanuela Handman, +2 more
- 01 May 1990 - 

Cloning of a gene encoding the immunodominant surface antigen of Leishmania donovani promastigotes.

Stephen Heath, +3 more
- 01 Apr 1987 - 

Molecular characterization of a Leishmania donovanii cDNA clone with similarity to human 20S proteasome a-type subunit.

Claus Christensen, +8 more
- 03 Jan 2000 -