Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TLDR
Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.Abstract:
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.read more
Citations
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Common human Toll‐like receptor 9 polymorphisms and haplotypes: association with atopy and functional relevance
Beate Berghöfer,Ture Frommer,Inke R. König,Andreas Ziegler,Trinad Chakraborty,Gregor Bein,Holger Hackstein +6 more
TL;DR: Synthetic CpG‐oligodeoxynucleotides (CPG‐ODNs) represent a promising and novel class of immune adjuvants for allergy treatment, vaccination, and cancer therapy, however, common functional TLR9 gene variants could interfere with the clinical utilization of Cpg‐ODN in immunotherapy.
Journal ArticleDOI
Mechanisms of Antiviral Immune Evasion of SARS-CoV-2
TL;DR: In this article , a detailed understanding of the host-pathogen interactions that unbalance the IFN response is critical for the design and deployment of host-targeted therapeutics to manage COVID-19.
Journal ArticleDOI
CCL2 expression is mediated by type I IFN receptor and recruits NK and T cells to the lung during MVA infection
Michael H. Lehmann,Lino E. Torres-Domínguez,Philip J. R. Price,Christine Brandmüller,Carsten J. Kirschning,Gerd Sutter +5 more
TL;DR: It is concluded that type I interferons, besides their known antiviral properties, can initiate the recruitment and activation of leukocytes via induction of chemokine expression including CCL2.
Journal ArticleDOI
Two distinct activation states of plasmacytoid dendritic cells induced by influenza virus and CpG 1826 oligonucleotide.
Amaya Iparraguirre,John W. Tobias,Scott E. Hensley,Katherine S. Masek,Lois L. Cavanagh,Michael Rendl,Christopher A. Hunter,Hildegund C. J. Ertl,Ulrich H. von Andrian,Wolfgang Weninger +9 more
TL;DR: In this paper, a transgenic mouse model that facilitates the isolation of highly pure plasmacytoid dendritic cells (pDC) populations was used to investigate the effect of pathogen recognition on pDC activation and function.
Journal ArticleDOI
Spatiotemporal regulation of type I interferon expression determines the antiviral polarization of CD4+ T cells.
Marco De Giovanni,Valeria Cutillo,Amir Giladi,Eleonora Sala,Carmela G. Maganuco,Chiara Medaglia,Pietro Di Lucia,Elisa Bono,Claudia Cristofani,Eleonora Consolo,Leonardo Giustini,Alessandra Fiore,Sarah Eickhoff,Wolfgang Kastenmüller,Ido Amit,Mirela Kuka,Matteo Iannacone +16 more
TL;DR: It is shown that the spatiotemporal regulation of type I interferon expression shapes the differentiation of antiviral CD4+ T cells into TFH or TH1 cells.
References
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Journal ArticleDOI
Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
TL;DR: This sequence allowed the determination of the hitherto unknown primary structure of rat GAPDH which is 333 aminoacids long and revealed a high degree of sequence conservation at both nucleotide and protein levels.
Journal ArticleDOI
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
TL;DR: A positive and negative selection procedure is described that enriches 2,000-fold for those cells that contain a targeted mutation in mouse embryo-derived stem cells.
Journal ArticleDOI
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
Hansruedi Büeler,Marek Fischer,Yolande Lang,Yolande Lang,Horst Bluethmann,Horst Bluethmann,Hans-Peter Lipp,Stephen J. DeArmond,Stephen J. DeArmond,Stanley B. Prusiner,Stanley B. Prusiner,Michel Aguet,Charles Weissmann +12 more
TL;DR: It is now feasible to determine whether mice devoid of PrPc can propagate prions and are susceptible to scrapie pathogenesis.
Journal ArticleDOI
Immune response in mice that lack the interferon-gamma receptor.
Sui Huang,Wiljan Hendriks,Alana Althage,Silvio Hemmi,Horst Bluethmann,Ryutaro Kamijo,Jan Vilcek,Rolf M. Zinkernagel,Michel Aguet +8 more
TL;DR: Mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
Journal ArticleDOI
Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements
Masaaki Miyamoto,Takashi Fujita,Yoko Kimura,Mitsuo Maruyama,Hisashi Harada,Yoshiaki Sudo,Takashi Miyata,Tadatsugu Taniguchi +7 more
TL;DR: It is shown here that the IRF-1 gene possesses virus-inducible promoter and is also involved in the regulation of other genes such as IFN-alpha and MHC class I genes.