Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TLDR
Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.Abstract:
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.read more
Citations
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Journal ArticleDOI
Modified Vaccinia Virus Ankara Induces Toll-Like Receptor-Independent Type I Interferon Responses
Zoe Waibler,Martina Anzaghe,Holger Ludwig,Shizuo Akira,Siegfried Weiss,Gerd Sutter,Ulrich Kalinke +6 more
TL;DR: MVA-mediated type I IFN secretion was primarily triggered by non-TLR molecules, was independent of virus propagation, and critically involved IFN feedback stimulation, which provides the basis to further improve MVA as a vaccine vector.
Book ChapterDOI
Cellular and molecular biology of optineurin
Hongyu Ying,Beatrice Y.J.T. Yue +1 more
TL;DR: Mutation or alteration of homeostasis of optineurin results in adverse consequences in the cells, leading to the development of neurodegenerative diseases including glaucoma.
Journal ArticleDOI
Type I Interferon Induces Inhibitory 16-kD CCAAT/ Enhancer Binding Protein (C/EBP)β, Repressing the HIV-1 Long Terminal Repeat in Macrophages: Pulmonary Tuberculosis Alters C/EBP Expression, Enhancing HIV-1 Replication
Yoshihiro Honda,Linda Rogers,Koh Nakata,Ben-Yang Zhao,Richard Pine,Yushi Nakai,Katsushi Kurosu,William N. Rom,Michael D. Weiden +8 more
TL;DR: In vitro THP-1 cell–derived macrophages inhibited HIV-1 replication after infection with Mycobacterium tuberculosis and proinflammatory stimulation produces an IFN response inhibiting viral replication by induction of a C/EBPβ transcriptional repressor.
Journal ArticleDOI
Long-term neuroinflammation induced by influenza A virus infection and the impact on hippocampal neuron morphology and function
Shirin Hosseini,Esther Wilk,Kristin Michaelsen-Preusse,Ingo Gerhauser,Wolfgang Baumgärtner,Robert Geffers,Klaus Schughart,Klaus Schughart,Martin Korte +8 more
TL;DR: Evidence is provided that neuroinflammation induced by neurotropic H7N7 and infection of the lung with a non-neurotropic H3N2 IAV result in long-term impairments in the CNS, indicating that IAV-associated inflammation induced functional and structural alterations in hippocampal networks.
Journal ArticleDOI
Enterovirus 71 Disrupts Interferon Signaling by Reducing the Level of Interferon Receptor 1
Jing Lu,Lina Yi,Jin Zhao,Jin Zhao,Jun Yu,Ying Chen,Marie C. Lin,Hsiang-Fu Kung,Ming-Liang He +8 more
TL;DR: The evidence is provided that EV71 antagonizes type I IFN signaling by reducing the level of interferon receptor 1 (IFNAR1) and identifies the 2A protease encoded by EV71 as an antagonist of IFNs and shows that the protease activity is required for reducing IFNAR 1 levels.
References
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Journal ArticleDOI
Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
TL;DR: This sequence allowed the determination of the hitherto unknown primary structure of rat GAPDH which is 333 aminoacids long and revealed a high degree of sequence conservation at both nucleotide and protein levels.
Journal ArticleDOI
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
TL;DR: A positive and negative selection procedure is described that enriches 2,000-fold for those cells that contain a targeted mutation in mouse embryo-derived stem cells.
Journal ArticleDOI
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
Hansruedi Büeler,Marek Fischer,Yolande Lang,Yolande Lang,Horst Bluethmann,Horst Bluethmann,Hans-Peter Lipp,Stephen J. DeArmond,Stephen J. DeArmond,Stanley B. Prusiner,Stanley B. Prusiner,Michel Aguet,Charles Weissmann +12 more
TL;DR: It is now feasible to determine whether mice devoid of PrPc can propagate prions and are susceptible to scrapie pathogenesis.
Journal ArticleDOI
Immune response in mice that lack the interferon-gamma receptor.
Sui Huang,Wiljan Hendriks,Alana Althage,Silvio Hemmi,Horst Bluethmann,Ryutaro Kamijo,Jan Vilcek,Rolf M. Zinkernagel,Michel Aguet +8 more
TL;DR: Mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
Journal ArticleDOI
Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements
Masaaki Miyamoto,Takashi Fujita,Yoko Kimura,Mitsuo Maruyama,Hisashi Harada,Yoshiaki Sudo,Takashi Miyata,Tadatsugu Taniguchi +7 more
TL;DR: It is shown here that the IRF-1 gene possesses virus-inducible promoter and is also involved in the regulation of other genes such as IFN-alpha and MHC class I genes.