Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TLDR
Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.Abstract:
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.read more
Citations
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A null mutation in the gene encoding a type I interferon receptor component eliminates antiproliferative and antiviral responses to interferons alpha and beta and alters macrophage responses
Seung Y. Hwang,Paul J. Hertzog,Kerry A. Holland,Sony H. Sumarsono,Martin J. Tymms,John A. Hamilton,Genevieve Whitty,Ivan Bertoncello,Ismail Kola +8 more
TL;DR: It is demonstrated that type I IFNs function in the development and responses of myeloid lineage cells, particularly macrophages, and that the IFNAR1 receptor component is essential for antiproliferative and antiviral responses to IFN-alpha and -beta.
Journal ArticleDOI
Interferons Direct Th2 Cell Reprogramming to Generate a Stable GATA-3+T-bet+ Cell Subset with Combined Th2 and Th1 Cell Functions
Ahmed N. Hegazy,Ahmed N. Hegazy,Michael Peine,Michael Peine,Caroline Helmstetter,Caroline Helmstetter,Isabel Panse,Isabel Panse,Anja Fröhlich,Anja Fröhlich,Andreas Bergthaler,Lukas Flatz,Daniel D. Pinschewer,Andreas Radbruch,Max Löhning,Max Löhning +15 more
TL;DR: Functional reprogramming of unfavorably differentiated Th2 cells may facilitate the establishment of protective immune responses and provide a molecular concept for the long-term coexistence of Th2 and Th1 cell lineage characteristics in single memory T cells.
Journal ArticleDOI
Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon.
Luisa Cervantes-Barragan,Roland Züst,Friedemann Weber,Martin Spiegel,Karl S. Lang,Shizuo Akira,Volker Thiel,Burkhard Ludewig +7 more
TL;DR: In this article, plasmacytoid dendritic cells (pDCs) and pDC-derived type I interferons (IFNs) were demonstrated to be essential for the control of potentially lethal coronavirus infections.
Journal ArticleDOI
Antiviral defense in mice lacking both alpha/beta and gamma interferon receptors.
TL;DR: Mice generated with a combined receptor defect showed an additive phenotype with respect to antiviral defense and exhibited an increased susceptibility to lymphocytic choriomeningitis virus and notably vaccinia virus infection.
Journal ArticleDOI
Regulation of Macrophage Activation
Jian Ma,T. Chen,Jami Mandelin,A. Ceponis,N. E. Miller,Mika Hukkanen,G. F. Ma,Yrjö T. Konttinen +7 more
TL;DR: Particle-induced macrophage activation was shown to differ from classical and alternate activation, showing in DNA microarray experiments (complete linkage/ Euclidean distance metric analysis) upregulation of nonsecreted structural/signaling molecules and lack of secreted proin-flammatory cyto- and chemokines.
References
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Journal ArticleDOI
Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
TL;DR: This sequence allowed the determination of the hitherto unknown primary structure of rat GAPDH which is 333 aminoacids long and revealed a high degree of sequence conservation at both nucleotide and protein levels.
Journal ArticleDOI
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
TL;DR: A positive and negative selection procedure is described that enriches 2,000-fold for those cells that contain a targeted mutation in mouse embryo-derived stem cells.
Journal ArticleDOI
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
Hansruedi Büeler,Marek Fischer,Yolande Lang,Yolande Lang,Horst Bluethmann,Horst Bluethmann,Hans-Peter Lipp,Stephen J. DeArmond,Stephen J. DeArmond,Stanley B. Prusiner,Stanley B. Prusiner,Michel Aguet,Charles Weissmann +12 more
TL;DR: It is now feasible to determine whether mice devoid of PrPc can propagate prions and are susceptible to scrapie pathogenesis.
Journal ArticleDOI
Immune response in mice that lack the interferon-gamma receptor.
Sui Huang,Wiljan Hendriks,Alana Althage,Silvio Hemmi,Horst Bluethmann,Ryutaro Kamijo,Jan Vilcek,Rolf M. Zinkernagel,Michel Aguet +8 more
TL;DR: Mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
Journal ArticleDOI
Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements
Masaaki Miyamoto,Takashi Fujita,Yoko Kimura,Mitsuo Maruyama,Hisashi Harada,Yoshiaki Sudo,Takashi Miyata,Tadatsugu Taniguchi +7 more
TL;DR: It is shown here that the IRF-1 gene possesses virus-inducible promoter and is also involved in the regulation of other genes such as IFN-alpha and MHC class I genes.