Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TLDR
Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.Abstract:
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.read more
Citations
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Journal ArticleDOI
Mice Lacking the Type I Interferon Receptor Are Resistant to Listeria monocytogenes
Victoria Auerbuch,Dirk G. Brockstedt,Nicole Meyer-Morse,Mary X. D. O'Riordan,Daniel A. Portnoy +4 more
TL;DR: In this article, the role of type I IFNs in immunity to bacterial pathogens was examined by examining the infection of Listeria monocytogenes in BALB/c mice lacking the type I interferon (IFN)-β.
Journal ArticleDOI
Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration
Mathias Heikenwalder,Magdalini Polymenidou,Tobias Junt,Christina J. Sigurdson,Hermann Wagner,Shizuo Akira,Rolf M. Zinkernagel,Adriano Aguzzi +7 more
TL;DR: It is reported that daily injection of 60 μg CpG-ODN dramatically alters the morphology and functionality of mouse lymphoid organs and strongly reduced primary humoral immune responses and immunoglobulin class switching.
Journal ArticleDOI
Type III Interferon (IFN) Induces a Type I IFN-Like Response in a Restricted Subset of Cells through Signaling Pathways Involving both the Jak-STAT Pathway and the Mitogen-Activated Protein Kinases
TL;DR: A detailed comparison of signal transduction initiated by type I and type III IFN is described and it is found that typeIII IFN relies strongly upon both p38 and JNK MAP kinases for gene induction.
Journal ArticleDOI
Toll-Like Receptors and RNA Helicases: Two Parallel Ways to Trigger Antiviral Responses
Etienne Meylan,Jürg Tschopp +1 more
TL;DR: The mechanistic aspects of these important arms of the host innate response to dsRNA and a few viral strategies utilized to counteract them are discussed.
Journal ArticleDOI
IL-15 is expressed by dendritic cells in response to type I IFN, double-stranded RNA, or lipopolysaccharide and promotes dendritic cell activation.
TL;DR: IL-15 is identified as a stimulatory cytokine for DCs with the potential for autocrine activity and its effects to expression of IFN-αβ are linked.
References
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Journal ArticleDOI
Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
TL;DR: This sequence allowed the determination of the hitherto unknown primary structure of rat GAPDH which is 333 aminoacids long and revealed a high degree of sequence conservation at both nucleotide and protein levels.
Journal ArticleDOI
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
TL;DR: A positive and negative selection procedure is described that enriches 2,000-fold for those cells that contain a targeted mutation in mouse embryo-derived stem cells.
Journal ArticleDOI
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
Hansruedi Büeler,Marek Fischer,Yolande Lang,Yolande Lang,Horst Bluethmann,Horst Bluethmann,Hans-Peter Lipp,Stephen J. DeArmond,Stephen J. DeArmond,Stanley B. Prusiner,Stanley B. Prusiner,Michel Aguet,Charles Weissmann +12 more
TL;DR: It is now feasible to determine whether mice devoid of PrPc can propagate prions and are susceptible to scrapie pathogenesis.
Journal ArticleDOI
Immune response in mice that lack the interferon-gamma receptor.
Sui Huang,Wiljan Hendriks,Alana Althage,Silvio Hemmi,Horst Bluethmann,Ryutaro Kamijo,Jan Vilcek,Rolf M. Zinkernagel,Michel Aguet +8 more
TL;DR: Mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
Journal ArticleDOI
Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements
Masaaki Miyamoto,Takashi Fujita,Yoko Kimura,Mitsuo Maruyama,Hisashi Harada,Yoshiaki Sudo,Takashi Miyata,Tadatsugu Taniguchi +7 more
TL;DR: It is shown here that the IRF-1 gene possesses virus-inducible promoter and is also involved in the regulation of other genes such as IFN-alpha and MHC class I genes.