Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TLDR
Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.Abstract:
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.read more
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The mengovirus leader protein blocks interferon-alpha/beta gene transcription and inhibits activation of interferon regulatory factor 3.
Stanleyson V. Hato,Céline Ricour,Barbara M. Schulte,Kjerstin Lanke,Mike A. M. De Bruijni,Jan Zoll,Willem J. G. Melchers,Thomas Michiels,Frank J. M. van Kuppeveld +8 more
TL;DR: It is suggested that the leader, by suppressing IRF3‐mediated IFN‐α/β production, plays an important role in replication and dissemination of mengovirus in its host.
Journal ArticleDOI
Differentiation of monocytes to macrophages switches the Mycobacterium tuberculosis effect on HIV-1 replication from stimulation to inhibition: modulation of interferon response and CCAAT/enhancer binding protein beta expression.
Michael D. Weiden,Naohiko Tanaka,Yaming Qiao,Ben Yang Zhao,Yoshihiro Honda,Koh Nakata,Antony Canova,David E. Levy,William N. Rom,Richard Pine +9 more
TL;DR: Results show that induction of ISGF-3, expression of the inhibitory 16-kDa C/EBPβ, and suppression of HIV-1 replication via a transcriptional mechanism are macrophage-specific responses to infection with M. tuberculosis.
Journal ArticleDOI
Embryo–maternal interactions at the implantation site: a delicate equilibrium
TL;DR: Interactions between trophoblast and uterine tissues and on cellular mechanisms and molecular signals involved in the closely regulated process of implantation are focused on.
Journal ArticleDOI
Selective loss of natural killer T cells by apoptosis following infection with lymphocytic choriomeningitis virus.
Jacqueline A. Hobbs,Sungyoo Cho,Tonya J. Roberts,Venkataraman Sriram,Jianhua Zhang,Ming Xu,Randy R. Brutkiewicz +6 more
TL;DR: The results suggest that the loss of NKT cells following an acuteLCMV infection could be due to the induction of IFN-α/β resulting in NKT-cell apoptosis and is important for the host's immune response to LCMV.
Journal ArticleDOI
Cross talk of the interferon‐α/β signalling complex with gp130 for effective interleukin‐6 signalling
Yukiko Mitani,Akinori Takaoka,Sunhwa Kim,Yukiko Kato,Taeko Yokochi,Nobuyuki Tanaka,Tadatsugu Taniguchi +6 more
TL;DR: This work has reported on the critical role of the IFN‐α/β signalling complex, generated by spontaneously producedIFN‐ α/β, in efficient IFN-γ signalling and the role of signalling cross talk in this complex.
References
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Journal ArticleDOI
Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
TL;DR: This sequence allowed the determination of the hitherto unknown primary structure of rat GAPDH which is 333 aminoacids long and revealed a high degree of sequence conservation at both nucleotide and protein levels.
Journal ArticleDOI
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
TL;DR: A positive and negative selection procedure is described that enriches 2,000-fold for those cells that contain a targeted mutation in mouse embryo-derived stem cells.
Journal ArticleDOI
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
Hansruedi Büeler,Marek Fischer,Yolande Lang,Yolande Lang,Horst Bluethmann,Horst Bluethmann,Hans-Peter Lipp,Stephen J. DeArmond,Stephen J. DeArmond,Stanley B. Prusiner,Stanley B. Prusiner,Michel Aguet,Charles Weissmann +12 more
TL;DR: It is now feasible to determine whether mice devoid of PrPc can propagate prions and are susceptible to scrapie pathogenesis.
Journal ArticleDOI
Immune response in mice that lack the interferon-gamma receptor.
Sui Huang,Wiljan Hendriks,Alana Althage,Silvio Hemmi,Horst Bluethmann,Ryutaro Kamijo,Jan Vilcek,Rolf M. Zinkernagel,Michel Aguet +8 more
TL;DR: Mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
Journal ArticleDOI
Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements
Masaaki Miyamoto,Takashi Fujita,Yoko Kimura,Mitsuo Maruyama,Hisashi Harada,Yoshiaki Sudo,Takashi Miyata,Tadatsugu Taniguchi +7 more
TL;DR: It is shown here that the IRF-1 gene possesses virus-inducible promoter and is also involved in the regulation of other genes such as IFN-alpha and MHC class I genes.