Journal ArticleDOI
Functional role of type I and type II interferons in antiviral defense.
Ulrike Müller,Ulrich Steinhoff,Luiz F. L. Reis,Silvio Hemmi,Jovan Pavlovic,Rolf M. Zinkernagel,Michel Aguet +6 more
TLDR
Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.Abstract:
Mice lacking the known subunit of the type I interferon (IFN) receptor were completely unresponsive to type I IFNs, suggesting that this receptor chain is essential for type I IFN-mediated signal transduction. These mice showed no overt anomalies but were unable to cope with viral infections, despite otherwise normal immune responses. Comparison of mice lacking either type I or type II IFN receptors showed that, at least in response to some viruses, both IFN systems are essential for antiviral defense and are functionally nonredundant.read more
Citations
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Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons.
Josh Gregorio,Josh Gregorio,Stephan Meller,Curdin Conrad,Anna Di Nardo,Bernhard Homey,Antti Lauerma,Naoko Arai,Richard L. Gallo,John DiGiovanni,Michel Gilliet,Michel Gilliet +11 more
TL;DR: Cutaneous injury in mice drives transient TLR7- and TLR9-mediated production of type I interferon by plasmacytoid dendritic cells, which is required for re-epithelialization of the skin.
Journal ArticleDOI
Measles Virus Spread and Pathogenesis in Genetically Modified Mice
Branka Mrkic,Jovan Pavlovic,Thomas Rülicke,Pietro Volpe,Christian J. Buchholz,Dennis E. Hourcade,John P. Atkinson,Adriano Aguzzi,Roberto Cattaneo +8 more
TL;DR: It is concluded that in mice alpha/beta interferon controls MV infection and that a high-affinity receptor facilitates, but is not strictly required for, MV spread and pathogenesis.
Journal ArticleDOI
Interferon-λ cures persistent murine norovirus infection in the absence of adaptive immunity.
Timothy J. Nice,Megan T. Baldridge,Broc T. McCune,Jason M. Norman,Helen M. Lazear,Maxim N. Artyomov,Michael S. Diamond,Herbert W. Virgin +7 more
TL;DR: Although the cytokines interferon-α (IFN-α) and IFN-β prevented the systemic spread of murine norovirus (MNoV), only IFn-λ controlled persistent enteric infection, and results suggest the therapeutic potential ofifN-λ for curing virus infections in the gastrointestinal tract.
Journal ArticleDOI
Interferon-α as an immunotherapeutic protein
TL;DR: The current state of knowledge of IFN‐α as an immunoregulatory protein is described and specific issues of IFn‐αAs an immunotherapeutic for antineoplastic and antiviral diseases are addressed.
Journal ArticleDOI
The roles of perforin- and Fas-dependent cytotoxicity in protection against cytopathic and noncytopathic viruses.
David Kägi,Peter Seiler,Jovan Pavlovic,Birgit Ledermann,Kurt Bürki,Rolf M. Zinkernagel,Hans Hengartner +6 more
TL;DR: It is suggested that perforin‐dependent cytotoxicity mediated by T cells is crucial for protection against noncytopathic viruses, whereas infections with cytopATHic viruses are controlled by nonlytic T cell‐dependent soluble mediators such as cytokines and neutralizing antibodies.
References
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Journal ArticleDOI
Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family
TL;DR: This sequence allowed the determination of the hitherto unknown primary structure of rat GAPDH which is 333 aminoacids long and revealed a high degree of sequence conservation at both nucleotide and protein levels.
Journal ArticleDOI
Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
TL;DR: A positive and negative selection procedure is described that enriches 2,000-fold for those cells that contain a targeted mutation in mouse embryo-derived stem cells.
Journal ArticleDOI
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein
Hansruedi Büeler,Marek Fischer,Yolande Lang,Yolande Lang,Horst Bluethmann,Horst Bluethmann,Hans-Peter Lipp,Stephen J. DeArmond,Stephen J. DeArmond,Stanley B. Prusiner,Stanley B. Prusiner,Michel Aguet,Charles Weissmann +12 more
TL;DR: It is now feasible to determine whether mice devoid of PrPc can propagate prions and are susceptible to scrapie pathogenesis.
Journal ArticleDOI
Immune response in mice that lack the interferon-gamma receptor.
Sui Huang,Wiljan Hendriks,Alana Althage,Silvio Hemmi,Horst Bluethmann,Ryutaro Kamijo,Jan Vilcek,Rolf M. Zinkernagel,Michel Aguet +8 more
TL;DR: Mutant mice offer the possibility for the further elucidation of IFN-gamma-mediated functions by transgenic cell- or tissue-specific reconstitution of a functional receptor.
Journal ArticleDOI
Regulated expression of a gene encoding a nuclear factor, IRF-1, that specifically binds to IFN-β gene regulatory elements
Masaaki Miyamoto,Takashi Fujita,Yoko Kimura,Mitsuo Maruyama,Hisashi Harada,Yoshiaki Sudo,Takashi Miyata,Tadatsugu Taniguchi +7 more
TL;DR: It is shown here that the IRF-1 gene possesses virus-inducible promoter and is also involved in the regulation of other genes such as IFN-alpha and MHC class I genes.